Next Generation Sequencing of Childhood Soft Tissue Sarcomas to Identify Drivers of Primary and Metastatic Disease
N/A
18 Years
Both
Sarcoma
Trial Information
Next Generation Sequencing of Childhood Soft Tissue Sarcomas to Identify Drivers of Primary and Metastatic Disease
OBJECTIVES:
- To identify the key components of driver pathways of primary and secondary soft tissue
sarcomas.
- To perform the next-generation sequencing on primary versus normal on undifferentiated
sarcomas.
OUTLINE: Genomic DNA and RNA samples from undifferentiated sarcoma tumors are analyzed by
next-generation sequencing for somatic mutations. Normal matched lymphocytes and tissue are
also analyzed.
Inclusion Criteria
DISEASE CHARACTERISTICS:
- Banked childhood samples from the COG-D9902 soft tissue sarcoma biology and banking
study
- Rhabdomyosarcoma, NOS
PATIENT CHARACTERISTICS:
- Not specified
PRIOR CONCURRENT THERAPY:
- Not specified
Type of Study:
Observational
Study Design:
N/A
Outcome Measure:
Occurrence of somatic mutations in driver genes and mutations in other genes that occur individually
Safety Issue:
No
Principal Investigator
Poul Sorensen, MD, PhD
Investigator Role:
Principal Investigator
Investigator Affiliation:
British Columbia Cancer Agency
Authority:
United States: Federal Government
Study ID:
CDR0000699508
NCT ID:
NCT01342783
Start Date:
May 2011
Completion Date:
Related Keywords:
- Sarcoma
- metastatic childhood soft tissue sarcoma
- nonmetastatic childhood soft tissue sarcoma
- recurrent childhood soft tissue sarcoma
- previously treated childhood rhabdomyosarcoma
- previously untreated childhood rhabdomyosarcoma
- recurrent childhood rhabdomyosarcoma
- Sarcoma
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