Know Cancer

or
forgot password

Microwave Versus Radiofrequency Ablation for Hepatocellular Carcinoma: a Prospective Randomized Control Trial


Phase 3
18 Years
N/A
Open (Enrolling)
Both
Hepatocellular Carcinoma

Thank you

Trial Information

Microwave Versus Radiofrequency Ablation for Hepatocellular Carcinoma: a Prospective Randomized Control Trial


Inclusion Criteria:



- Age >18 years

- Unresectable hepatocellular carcinoma (HCC) and tumor amendable for local ablation

- Resectable HCC but patient opts for local ablation

- Maximum diameter of tumor ≤6cm

- Maximum number of tumor nodules ≤3

- Absence of radiology evidence of major vascular or bile duct invasion

- Child's A or B liver function

- Karnofsky performance status ≥70%

Exclusion Criteria:

- Informed consent not available

- Pregnant female patients

- Tumors unfavourable for local ablation (e.g. tumor close to porta hepatis)

- HCC with history of rupture

- Concomitant hepatectomy

- Patients with chronic renal failure

Type of Study:

Interventional

Study Design:

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Outcome Measure:

Complete ablation rate

Outcome Description:

Measure by post-ablation Computed Tomography (CT) with reference to alpha-fetoprotein (AFP)

Outcome Time Frame:

1 month

Safety Issue:

No

Principal Investigator

Kit-fai Lee, MBBS

Investigator Role:

Principal Investigator

Investigator Affiliation:

Division of Hepato-biliary and Pancreatic Surgery, Department of Surgery, The Chinese University of Hong Kong

Authority:

Hong Kong: Joint CUHK-NTEC Clinical Research Ethics Committee

Study ID:

CT11005

NCT ID:

NCT01340105

Start Date:

April 2011

Completion Date:

April 2016

Related Keywords:

  • Hepatocellular Carcinoma
  • Microwave ablation
  • Radiofrequency ablation
  • Randomised controlled trial
  • Carcinoma
  • Carcinoma, Hepatocellular

Name

Location