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Exercise and Inflammation: Autonomic, Affective & Cellular Mechanisms

20 Years
45 Years
Open (Enrolling)
Cardiovascular Disease

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Trial Information

Exercise and Inflammation: Autonomic, Affective & Cellular Mechanisms

Aerobic exercise - the most widely recommended health behavior - is recognized to reduce the
risk of coronary heart disease, so much so that consensus panels routinely include it as
part of a cardioprotective regimen for healthy people, but the physiological or mechanistic
basis of this protection is uncertain. Understanding the mechanisms has considerable public
health significance because it will allow development and testing of targeted interventions
to produce comparable cardioprotective effects more directly or in cases where aerobic
exercise is not possible. This application proposes to test the hypothesis that aerobic
training leads to attenuation of the inflammatory response to LPS stimulation and to examine
the role played by exercise-induced increases in vagal activity, improvements in mood, and
decreased expression of Toll Receptor 4 (TLR4), the cognate receptor for endotoxin expressed
by monocytes.

Inclusion Criteria:

1. Age 20-45 years old

2. English-speaking

3. Ambulatory Interview

4. BMI < 32

5. Pre-menopausal (women only) with regular cycle lengths between 26-32 days

6. "Average" fitness as determined by AHA standards (VO2max < 43 ml/kg/min for men, < 37
ml/kg/min for women) VO2max test

Exclusion Criteria:

1. Use of psychotropic medications

2. Past or current psychiatric disorder

3. Heart disease

4. Hypertension

5. Diabetes mellitus

6. Neurologic disease

7. Smoking

8. Any condition for which aerobic training is counterindicated

9. Use of any medication with autonomic effects

10. Use of birth control medication

11. Ischemic changes, abnormal blood pressure responses, significant ectopy

Type of Study:


Study Design:

Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Basic Science

Outcome Measure:

tumor necrosis factor (TNF-alpha)

Outcome Description:

TNF-alpha will be measured from whole blood samples stimulated with lipopolysaccharide

Outcome Time Frame:

change from before (pre) to after (post) 12 weeks of training & after 4 weeks of post-deconditioning

Safety Issue:


Principal Investigator

Richard P Sloan, PhD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Columbia University


United States: Institutional Review Board

Study ID:




Start Date:

January 2010

Completion Date:

December 2015

Related Keywords:

  • Cardiovascular Disease
  • Cardiovascular Diseases
  • Inflammation



Columbia University Medical CenterNew York, New York  10032