Exercise and Inflammation: Autonomic, Affective & Cellular Mechanisms
20 Years
45 Years
Both
Cardiovascular Disease
Trial Information
Exercise and Inflammation: Autonomic, Affective & Cellular Mechanisms
Aerobic exercise - the most widely recommended health behavior - is recognized to reduce the
risk of coronary heart disease, so much so that consensus panels routinely include it as
part of a cardioprotective regimen for healthy people, but the physiological or mechanistic
basis of this protection is uncertain. Understanding the mechanisms has considerable public
health significance because it will allow development and testing of targeted interventions
to produce comparable cardioprotective effects more directly or in cases where aerobic
exercise is not possible. This application proposes to test the hypothesis that aerobic
training leads to attenuation of the inflammatory response to LPS stimulation and to examine
the role played by exercise-induced increases in vagal activity, improvements in mood, and
decreased expression of Toll Receptor 4 (TLR4), the cognate receptor for endotoxin expressed
by monocytes.
Inclusion Criteria:
1. Age 20-45 years old
2. English-speaking
3. Ambulatory Interview
4. BMI < 32
5. Pre-menopausal (women only) with regular cycle lengths between 26-32 days
6. "Average" fitness as determined by AHA standards (VO2max < 43 ml/kg/min for men, < 37
ml/kg/min for women) VO2max test
Exclusion Criteria:
1. Use of psychotropic medications
2. Past or current psychiatric disorder
3. Heart disease
4. Hypertension
5. Diabetes mellitus
6. Neurologic disease
7. Smoking
8. Any condition for which aerobic training is counterindicated
9. Use of any medication with autonomic effects
10. Use of birth control medication
11. Ischemic changes, abnormal blood pressure responses, significant ectopy
Type of Study:
Interventional
Study Design:
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Basic Science
Outcome Measure:
tumor necrosis factor (TNF-alpha)
Outcome Description:
TNF-alpha will be measured from whole blood samples stimulated with lipopolysaccharide
Outcome Time Frame:
change from before (pre) to after (post) 12 weeks of training & after 4 weeks of post-deconditioning
Safety Issue:
No
Principal Investigator
Richard P Sloan, PhD
Investigator Role:
Principal Investigator
Investigator Affiliation:
Columbia University
Authority:
United States: Institutional Review Board
Study ID:
5948
NCT ID:
NCT01335737
Start Date:
January 2010
Completion Date:
December 2015
Related Keywords:
- Cardiovascular Disease
- Cardiovascular Diseases
- Inflammation
Name | Location |
|---|---|
| Columbia University Medical Center | New York, New York 10032 |
