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Survival After First Myocardial Infarction in Patients With and Without Chronic Obstructive Pulmonary Disease

18 Years
Open (Enrolling)
Myocardial Infarction, Chronic Obstructive Pulmonary Disease

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Trial Information

Survival After First Myocardial Infarction in Patients With and Without Chronic Obstructive Pulmonary Disease

This study is part of the CALIBER (Cardiovascular disease research using linked bespoke
studies and electronic records) programme funded over 5 years from the NIHR and Wellcome
Trust. The central theme of the CALIBER research is linkage of the Myocardial Ischaemia
National Audit Project (MINAP) with primary care (GPRD) and other resources. The overarching
aim of CALIBER is to better understand the aetiology and prognosis of specific coronary
phenotypes across a range of causal domains, particularly where electronic records provide a
contribution beyond traditional studies. CALIBER has received both Ethics approval (ref
09/H0810/16) and ECC approval (ref ECC 2-06(b)/2009 CALIBER dataset).


1. To investigate survival differences after first myocardial infarction in patients with
and without COPD.

2. To investigate if these survival differences exist due to a) differences in prevalence
of risk factors (e.g. smoking) b) differences in management after myocardial infarction
(e.g. uptake of cardiac rehabilitation, prescription of beta-blockers) and c) COPD
related events (e.g. exacerbations).

Inclusion Criteria:

- Patients in GPRD practices which are deemed "up to standard" by GPRD criteria will be
included if their practice agreed to be linked to the MINAP dataset.

- Age over 18.

Exclusion Criteria:

- Patients will be excluded after experiencing their first MI.

- Patients will be excluded if they do not fulfil one of the inclusion criteria.

Type of Study:


Study Design:

Observational Model: Cohort, Time Perspective: Retrospective

Outcome Measure:

Death after a first ST elevation or non ST elevation MI

Outcome Description:

The primary outcome is death after a first ST elevation or non ST elevation MI. Death information will be based on data from one or more of the following: ONS death certificates; Hospital Episode Statistics; MINAP data; GPRD data.

Outcome Time Frame:

Average time frame: patients in the GPRD are followed from registration until they experience the outcome, leave the practice, die, or 31st December 2009, whichever occurs first

Safety Issue:


Principal Investigator

Jennifer K Quint, MRCP PhD

Investigator Role:

Principal Investigator

Investigator Affiliation:

London School of Hygiene and Tropical Medicine


United Kingdom: CALIBER Scientific Oversight Committee

Study ID:




Start Date:

March 2011

Completion Date:

December 2014

Related Keywords:

  • Myocardial Infarction
  • Chronic Obstructive Pulmonary Disease
  • Myocardial infarction
  • chronic obstructive pulmonary disease
  • General Practice Research Database
  • Myocardial Ischaemia National Audit Project
  • Infarction
  • Lung Diseases
  • Respiration Disorders
  • Pulmonary Disease, Chronic Obstructive
  • Myocardial Infarction
  • Lung Diseases, Obstructive