Inclusion Criteria:

1. Age:20 to 70 years old, both male and female

2. Histologically proven T1 or T2 N0 M0 (clinical) squamous cell carcinoma of the oral
tongue, buccal mucosa, gingiva, floor of mouth, and hard palate

3. The maximum diameter of the primary tumor is less than 4cm

4. Clinical nodal staging has been confirmed negative via both clinical examination and
imaging (MRI or lateral and central neck ultrasound)

5. With at least 1-year's expected survival time

6. Willing to join the protocol and is able to give written informed consent

Exclusion Criteria:

1. Patient with severe cardiac insufficiency, hepatic insufficiency, renal
insufficiency, of systemic infection diseases

2. The patient is pregnant or lactating

3. Patients with a history of surgical treatment, radiotherapy, chemotherapy, biotherapy
and targeted therapy, et al, before participating in the study

4. Patient is currently participating in another investigational drug study