Development and Validation of a Circulating Tumor DNA Detection Technique in Patients With Metastatic Choroidal Melanoma
Technique development: In first step, the different available techniques will be evaluated
for specificity and sensibility using serial dilutions of cell lines with or without GNAQ
mutation.
Validation: The tumor DNA detection rate will be estimated from metastatic uveal patient's
blood. The investigators will study 40 patients to obtain at least 15 patients bearing a
GNAQ mutation in the primitive tumor or in metastasis. With those 15 patients, the
investigators will determinate the most sensitive technique and the best cost/efficiency
ratio.
Interventional
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic
Assessment and development of circulating tumor DNA detection techniques
Quantification of circulating tumor DNA in blood samples. Results expressed in number of samples where circulating DNA is present.
2 years
No
Sophie PIPERNO-NEUMANN, MD
Principal Investigator
Institut Curie
France: Afssaps - Agence française de sécurité sanitaire des produits de santé (Saint-Denis)
IC 2010-02
NCT01334008
April 2011
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