The Effect of Ischemic Preconditioning on Postoperative Pain After Total Knee Arthroplasty, a Randomized, Controlled Trial
During knee surgery your surgeon routinely uses a device called a tourniquet that allows us
to temporarily cut of blood supply to the site of surgery. This helps to reduce blood loss
and improves operating conditions. When allowing blood back into your leg at the end of the
procedure, debris (bone, fat, tissue breakdown products and cement from the surgery) gets
washed out and gains access to the rest of your body. In the vast majority of cases this
event bares no major clinical consequences, but can rarely result in signs of inflammation
of various body systems. Patients with evidence of impaired organ system function such as
pre-existing lung and heart disease may be more vulnerable. Previous studies suggest that
cutting off the blood supply for a short period of time just before a prolonged episode,
could lead to a decrease in the extent of tissue breakdown products in this extremity and
may thus be associated with a decrease in the inflammation of other organ systems. We
propose to study this theory in knee surgery patients by looking at levels of markers of
inflammation present in the blood before and after surgery.
Interventional
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Outcomes Assessor), Primary Purpose: Health Services Research
Postoperative pain at rest and exercise as assessed by VAS scores on 6h, 24h, and 48h after surgery
Up to 48hrs after surgery
No
Stavros G. Memtsoudis, MD, PhD
Principal Investigator
Hospital for Special Surgery, New York
United States: Institutional Review Board
HSS10131
NCT01333969
April 2011
Name | Location |
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Hospital for Special Surgery | New York, New York 10021 |