A Prospective Single Institution Study of Optic Neuropathy in 10 Patients With Glioblastoma Receiving Bevacizumab
The investigators research will focus on patients prior to them beginning treatment with
bevacizumab (Avastin), by undergoing a baseline visual examination with Visual evoked
Potentials testing. This will allow testing of the patient's optic nerve function
bilaterally. Patients will then begin their normally scheduled treatment with avastin, and
other chemotherapeutic agents, as well any radiation treatments scheduled. Once patients
have completed their treatment with avastin for 6-8 weeks, they will then undergo their
second Visual Evoked Potential testing, with both studies then being compared for any
changes within the optic nerves. Patients will also be recommended to have stringent follow
up with an Ophthalmologist to include confrontational visual field testing, external and
anterior segment examination, and dilated fundus examination. The investigators main
objective is to assess whether or not bevacizumab causes a direct toxic effect on patient's
optic nerves leading to an acute/subacute optic neuropathy.
Endpoint Classification: Safety Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
Measurement of Visual Evoked Potentials (optic nerve function and visual processing) and optic nerve function in 10 patients.
Does Avastin lead to optic neuropathy in combination w chemo-radiotherapy? Our research will focus on patients prior to them beginning treatment with bevacizumab (Avastin), by undergoing Visual evoked Potentials testing. This will allow testing of the patient's optic nerve function bilaterally. In our study of VEP, we will be measuring optic nerve function, to asses if there has been any damage.
United States: Alleghney General Hospital
|Allegheny General Neurology Department/Neuro-Oncology||Pittsburgh, Pennsylvania 15212|