HPV Prevalence in the Mouth and Oropharynx of the General Population
1 Year
55 Years
Both
Chronic Tonsillitis
Trial Information
HPV Prevalence in the Mouth and Oropharynx of the General Population
Patients undergoing a tonsillectomy operation for non-cancerous reasons will be recruited
for this study. They will be asked to complete two questionnaires (study and sexual
practices), provide saliva, urine and a blood sample. Following anaesthesia, oral mucosal
scrappings and a tonsillectomy will be performed and all the samples will be processed for
evidence of HPV infection.
Inclusion Criteria:
1. Subjects undergoing tonsillectomy for non cancer reasons including operations for:
recurrent tonsillitis, asymmetric tonsils, snoring surgery or obstructive sleep
apnoea
2. Age - 0 to 55 years
3. Subject or legal guardian has given informed written consent
Exclusion Criteria:
1. Subjects undergoing adenoidectomy alone with no tonsillectomy
2. Subjects with previous oropharyngeal cancer or oral cancer, or any other head and
neck cancer such as nasopharyngeal or laryngeal cancer that is currently undergoing
or has previously been diagnosed or treated
3. Learning disability preventing an adult over 16 years old from giving their own
consent
Type of Study:
Observational
Study Design:
Observational Model: Cohort, Time Perspective: Prospective
Outcome Measure:
Occurrence of HPV in tonsils and in oral scrape sample
Outcome Time Frame:
3 months
Safety Issue:
No
Principal Investigator
Hisham Mehanna, FRCS, PhD
Investigator Role:
Principal Investigator
Investigator Affiliation:
University Hospitals Coventry and Warwickshire NHS Trust
Authority:
United Kingdom: National Health Service
Study ID:
HM086011
NCT ID:
NCT01330147
Start Date:
August 2011
Completion Date:
July 2015
Related Keywords:
- Chronic Tonsillitis
- HPV
- oral cancer
- oropharyngeal cancer
- tonsillectomy
- Tonsillitis
- Chronic Disease
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