Inclusion Criteria

Inclusion criteria:

1. Female patients, age 20 years or older, with relapse of histologically (on initial
diagnosis) confirmed epithelial ovarian cancer, fallopian tube carcinoma or primary
peritoneal cancer

2. Up to 3 lines of prior chemo therapy, with treatment free interval of >6 months

3. Platinum based chemotherapy in the immediately preceding line.

4. Eastern Cooperative Oncology Group (ECOG) performance score 0 or 1

5. Written informed consent that is consistent with Good Clinical Practice (GCP)
guidelines

Exclusion criteria:

1. Prior chemotherapy with PLD, and any contraindication for therapy with carboplatin or
PLD.

2. More than 2 lines of prior therapies that contained angiogenesis inhibitor.

3. Patients for whom surgery is planned, e.g. interval debulking surgery.

4. History of a cerebral vascular accident, transient ischemic attack or subarachnoid
haemorrhage within the past 6 months.

5. Serious infections in particular if requiring systemic antibiotic (antimicrobial,
antifungal) or antiviral therapy.

6. Laboratory values indicating an increased risk for adverse events.

7. Significant cardiovascular diseases.