The Relationship of Serum 25-Hydroxyvitamin D to Overall Survival in Advanced Pancreatic Cancer
- To measure baseline serum 25-hydroxyvitamin D (25[OH]D) levels in a cohort of patients
with advanced pancreatic cancer enrolled in the Cancer and Leukemia Group B (CALGB)
study 80303 and evaluate the association between vitamin D status and overall survival
- To evaluate the association between common germ-line single nucleotide polymorphisms
(SNPs) in the vitamin D pathway genes and 25(OH)D levels in patients with advanced
- To evaluate the interaction between serum 25(OH)D levels and germ-line SNPs in the
vitamin D pathway genes in predicting OS in advanced pancreatic cancer.
OUTLINE: This is a multicenter study.
Archived serum samples are analyzed for 25-hydroxyvitamin D levels by competitive
chemiluminescence immunoassay. Results are then compared with the germ-line single
nucleotide polymorphisms from the Genome-Wide Association Study (GWAS) and patients'
Association between 25(OH)D level and OS
Alan P. Venook, MD
University of California, San Francisco
|Charles R. Wood Cancer Center at Glens Falls Hospital||Glens Falls, New York 12801|