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Detection of Clonal Mast Cell Disorders Among Patients With Exercise-induced Anaphylaxis


N/A
21 Years
N/A
Open (Enrolling)
Both
Anaphylaxis

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Trial Information

Detection of Clonal Mast Cell Disorders Among Patients With Exercise-induced Anaphylaxis


Inclusion Criteria:



- Anaphylaxis in association with exercise on at least two occasions

- During anaphylactic reaction, the subject must have experienced one or more of the
following: flushing, hypotension, lack of urticaria

Exclusion Criteria:

- Pregnancy

Type of Study:

Observational

Study Design:

Observational Model: Cohort, Time Perspective: Retrospective

Outcome Measure:

Number of participants with presence of clonal abnormalities in the bone marrow specimen

Outcome Description:

Presence of clonal mast cells in bone marrow as assessed by D816V c-kit mutation or CD25 will be recorded for each participant.

Outcome Time Frame:

Baseline

Safety Issue:

No

Authority:

United States: Institutional Review Board

Study ID:

2010P002042

NCT ID:

NCT01326741

Start Date:

March 2011

Completion Date:

Related Keywords:

  • Anaphylaxis
  • clonal mast cell disorder
  • exercise-induced anaphylaxis
  • hypotension
  • Anaphylaxis
  • Mastocytosis

Name

Location

Brigham and Women's HospitalBoston, Massachusetts  02115