Inclusion Criteria

- INCLUSION CRITERIA:

- Female and male subjects, age 18 to 55 and in good health as determined by past
medical history, physical examination, vital signs, electrocardiogram, and laboratory
tests.

- Body mass index (BMI) must be within the range of 18 to 30 kg/m(2), inclusive

- Vital signs should be within the following ranges at screening and baseline:

1. Oral body temperature between 35.0-37.5 degree C

2. Systolic blood pressure, 85-140 mm Hg

3. Diastolic blood pressure, 50-90 mm Hg

4. Pulse rate, 50 - 100 bpm

- Ability to provide an informed consent.

- Blood tests demonstrating normal physiologic organ functions:

1. Hematological (neutrophils greater than or equal to 1000; hemoglobin greater
than or equal to 12 g/dl (female) and greater than or equal to 14g/dl (male);
platelets > 150,000).

2. Creatinine (Cre < 1.5 times ULN)

3. LFTs (SGOT, SGPT, < 2.5 times ULN)

4. PT and/or PTT < 1.5 times ULN

EXCLUSION CRITERIA:

- Participation in any clinical investigation within 4 weeks prior to dosing or longer
if required by local regulations, and for any other limitation of participation based
on local regulations.

- Significant illness within two weeks prior to dosing.

- History of clinically significant drug allergy or history of atopic allergy (asthma,
urticaria, eczematous dermatitis)

- History of chronic skin disease that might interfere with IDEP application

- Known allergic reactions to adhesive tape

- History of use of chronic or current pain medication (narcotics)

- Sunburn or tattoos at the application sites (both shoulders)

- Subject has a pacemaker or implanted defibrillator

- A past medical history of clinically significant EKG abnormalities or a family
history (grandparents, parents and siblings) of a sudden cardiac death or
dysrhythmia.

- History of drug or alcohol abuse within the 12 months prior to dosing.

- History of noncompliance to medical regimens or unwillingness to comply with the
study protocol

- History of HIV or hepatitis B or C.

- Pregnancy

- Known allergy to local anesthetics such as lidocaine