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Detection of Choroidal Nevus Cells in Vitrectomy Fluid

18 Years
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Trial Information

Detection of Choroidal Nevus Cells in Vitrectomy Fluid

Approximately 7% of the population has a choroidal nevus, or "freckle," in the back of the
eye. Like a nevus on the skin, there is potential for malignant change to a melanoma.
Dermatologists have the ability to quickly and easily biopsy suspicious skin lesions while
ophthalmologists currently have no way of determining the malignant potential of choroidal
nevi other than a fine needle aspiration (which is invasive and has the potential
complications of bleeding and retinal detachment). This study's sole aim is to see if
choroidal nevi cells are present in the inside fluid of the eye. The investigators plan to
analyze the fluid of the eye, which is routinely removed during retina surgery, to detect
any nevus cells. If the investigators are able to detect these cells, then future studies
may allow us to better classify choroidal nevi for potential malignant change.

Inclusion Criteria:

- Patients with a choroidal nevus who are undergoing routine vitrectomy surgery for
another indication (such as epiretinal membrane or macular hole repair).

Exclusion Criteria:

- Patients without a choroidal nevus

- Children under the age of 18

- Pregnant and nursing females

Type of Study:


Study Design:

Observational Model: Cohort, Time Perspective: Prospective

Outcome Measure:

Positive identification of nevus cells in eye fluid

Outcome Time Frame:

1 day

Safety Issue:


Principal Investigator

Dr. Darius M. Moshfeghi

Investigator Role:

Principal Investigator

Investigator Affiliation:

Stanford University


United States: Institutional Review Board

Study ID:




Start Date:

June 2010

Completion Date:

May 2013

Related Keywords:

  • Nevus
  • choroidal nevus
  • vitrectomy
  • Nevus
  • Nevus, Pigmented



Stanford University School of Medicine Stanford, California  94305-5317