A Prospective, Observational Analysis of Voriconazole (VOR) Therapeutic Drug Concentration Monitoring, Pharmacogenomics and Clinical Outcome Correlations in High-risk Hematology Patients at Princess Margaret Hospital
Observational Model: Cohort, Time Perspective: Prospective
To determine whether clinical responses (complete/partial/failure) directly correlate with patients' blood voriconazole levels.
The primary outcome measure is defined by the following endpoints: abefrile for at least 48 hours no breakthrough fungal infection resolution or improvement of radiological findings
Jack Seki, P.Ph, PharmD
University Health Network, Toronto
Canada: Ethics Review Committee