Effects of Different Strategy of Fluids Administration on Acid/Base Disorders and Inflammatory Mediators
18 Years
90 Years
Both
Carcinoma of the Large Intestine
Trial Information
Effects of Different Strategy of Fluids Administration on Acid/Base Disorders and Inflammatory Mediators
Inclusion Criteria:
- Patients with diagnosis of large bowel cancer
- Age > 18 years old
Exclusion Criteria:
Emergency surgery for bowel punch or intestinal occlusion
- Massive bleeding
- Therapy with corticosteroid or nonsteroid antiinflammatory substances
- Renal insufficiency (serum creatinine > 200 micromol /l)
- Cardiac insufficiency (NYHA III-IV)
- Altered liver function (ALT > 40 U/l AST >40 U/l)
- Preoperative anaemia ( Hb < 10 g/dl )
- Allergy to hydrossietilic starches
- Patient rejection to share the study
Type of Study:
Interventional
Study Design:
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
Outcome Measure:
acid/base disorder
Outcome Description:
the investigators assess difference in acid base disorders between the two groups measuring emogas analyses data and blood electrolites levels at the same time (two days)
Outcome Time Frame:
T0: anaesthesia induction (control value) T1: end of surgery T2: 1h after the end of surgery T3: 24h after the beginning of surgery
Safety Issue:
Yes
Principal Investigator
Carlo A Volta, Professor
Investigator Role:
Study Chair
Investigator Affiliation:
Ferrara Univesity
Authority:
Italy: The Italian Medicines Agency
Study ID:
HC-I-H-0909
NCT ID:
NCT01320891
Start Date:
February 2010
Completion Date:
Related Keywords:
- Carcinoma of the Large Intestine
- general anaesthesia for major abdominal surgery
- Carcinoma
- Colorectal Neoplasms
Name | Location |
|---|
