Inclusion Criteria:

- Age 18 years old or older

- Biliary obstruction by any malignant process with histologically or cytologically
confirmed by biopsy or previous surgical procedures

- Clinical symptoms of biliary obstruction

- Unresectable or refused to be surgically treated biliary obstruction by any malignant
process

- Willing and able to comply with the study procedures and provide written informed
consent to participate in the study

Exclusion Criteria:

- Suspected benign bile duct stricture

- Strictures that can not be dilated enough to pass the delivery system

- Perforation of any duct within the biliary tree

- Presence metallic biliary stent or bile duct surgery

- Patients for whom PTC procedures are contraindicated

- Patients with active hepatitis or intrahepatic metastases that extensively involves
both lobes of the liver

- Noncooperation or no authorization and signature