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PET-CT in Diagnosis of Pancreatic Cystic Neoplasms

18 Years
Open (Enrolling)
Neoplasms, Pancreatic Cancer

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Trial Information

PET-CT in Diagnosis of Pancreatic Cystic Neoplasms

Today, in clinical practice the diagnosis pancreatic cystic neoplasms are based on MDCT, MRI
and ERCP followed by surgical exploration. The information gained by conventional imaging
modalities is restricted to the morphological details, which usually is insufficient for the
definitive staging of the pancreatic cystic neoplasms. Based on these previous studies, it
seems that PET especially combined with CT modality could improve the diagnostic accuracy of
the pancreatic cystic lesions.

So far, there are only few cases published concerning the role of 18F-FDG-PET-CT in the
differential diagnosis of cystic pancreatic lesions. Therefore, more studies are needed to
determine the role of combined 18F-FDG-PET-CT in the diagnosis of pancreatic cystic lesions.

The aim of the current project is to evaluate the possibility to enhance the diagnostic
accuracy by using the combined 18F-FDG-PET-CT imaging in patients with pancreatic cystic
neoplasms by combining PET-CT with MRI and MDCT.

The study consists of 20-30 patients with pancreatic cystic neoplasms. The patients enrolled
in the study will be imaged by MDCT, MRI combined with magnetic resonance
cholangiopancreatography (MRCP), endoscopic retrograde cholangiopancreatography (ERCP) and
18F-FDG-PET-CT followed by surgery or follow-up. The data will be collected between 2011
and 2013.

Inclusion Criteria:

- suspicion of pancreatic cystic neoplasm using US, MDCT, MRI and/or ERCP

- laparotomy planned because of the lesion

- signed informed consent

Exclusion Criteria:


Type of Study:


Study Design:

Observational Model: Cohort, Time Perspective: Prospective

Outcome Measure:

Predictive Value of PET/CT imaging for Identifying Malignant and Benign Pancreatic Cystic Lesions

Outcome Description:

To determine sensitivities, specificities, accuracy and positive/negative predictive values of PET/CT imaging for differentiating malignant and benign cystic lesions in patients who are to undergo surgical resection.

Outcome Time Frame:

1 mo

Safety Issue:


Principal Investigator

Saila Kauhanen, PhD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Turku University Hospital


Finland: Ethics Committee

Study ID:




Start Date:

March 2011

Completion Date:

February 2013

Related Keywords:

  • Neoplasms
  • Pancreatic Cancer
  • pancreatic cystic lesion
  • PET
  • PET-CT
  • diagnosis
  • Neoplasms
  • Pancreatic Neoplasms