Trial Information
Determination of Predictive Genetic Markers of Toxicity After Hypofractionated Radiotherapy in Breast Cancer Patients Post-Conservative Surgery
Inclusion Criteria:
- Age ≥ 48 years old with a life expectancy of at least 5 years
- Post-menopausal status
- Histologically proven, non lobular, adenocarcinoma of the breast
- Primary tumours ≤ 3 cm
- Negative surgical margins (≥ 2 mm)
- Negative sentinel nodes or < 4 positive axillary nodes
- No extra-capsular extension
- No previous radiotherapy
Exclusion Criteria:
- multicentric disease
- extended intraductal component (EIC > 25%)
- Paget's disease
- lobular adenocarcinoma
- distant metastases All the above criteria allow to identify patients at low risk of
local recurrence.
Type of Study:
Observational
Study Design:
Observational Model: Cohort, Time Perspective: Prospective
Authority:
Italy: Ethics Committee
Study ID:
IFO-84/10
NCT ID:
NCT01316328
Start Date:
May 2010
Completion Date:
December 2010
Related Keywords:
- Breast Cancer
- toxicity after single shot partial breast irradiation (SSPBI)
- Breast Neoplasms