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Determination of Predictive Genetic Markers of Toxicity After Hypofractionated Radiotherapy in Breast Cancer Patients Post-Conservative Surgery


N/A
48 Years
90 Years
Not Enrolling
Female
Breast Cancer

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Trial Information

Determination of Predictive Genetic Markers of Toxicity After Hypofractionated Radiotherapy in Breast Cancer Patients Post-Conservative Surgery


Inclusion Criteria:



- Age ≥ 48 years old with a life expectancy of at least 5 years

- Post-menopausal status

- Histologically proven, non lobular, adenocarcinoma of the breast

- Primary tumours ≤ 3 cm

- Negative surgical margins (≥ 2 mm)

- Negative sentinel nodes or < 4 positive axillary nodes

- No extra-capsular extension

- No previous radiotherapy

Exclusion Criteria:

- multicentric disease

- extended intraductal component (EIC > 25%)

- Paget's disease

- lobular adenocarcinoma

- distant metastases All the above criteria allow to identify patients at low risk of
local recurrence.

Type of Study:

Observational

Study Design:

Observational Model: Cohort, Time Perspective: Prospective

Authority:

Italy: Ethics Committee

Study ID:

IFO-84/10

NCT ID:

NCT01316328

Start Date:

May 2010

Completion Date:

December 2010

Related Keywords:

  • Breast Cancer
  • toxicity after single shot partial breast irradiation (SSPBI)
  • Breast Neoplasms

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