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Pilot Case-Control Study of WT1 Mutations in Wilms Tumor Patients Who Develop ESRD


N/A
N/A
15 Years
Open (Enrolling)
Both
Kidney Cancer, Renal Failure

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Trial Information

Pilot Case-Control Study of WT1 Mutations in Wilms Tumor Patients Who Develop ESRD


OBJECTIVES:

- To determine whether Wilms Tumor (WT) patients without WT1-associated congenital
anomalies or syndromes, but with end-stage renal disease (ESRD) unrelated to
progressive bilateral tumors, carry germline WT1 mutations.

- To determine whether non-syndromic WT1 germline mutation carriers have a substantially
higher incidence of ESRD than do WT patients who do not harbor WT1 mutations.

OUTLINE: Archived blood and tumor tissue specimens (or DNA isolated from these samples) are
analyzed for WT1 mutations by gene sequencing and PCR.

Inclusion Criteria


DISEASE CHARACTERISTICS:

- Diagnosis of Wilms Tumor (WT)

- Patients who participated in the NWTS-5 protocol

- Non-syndromic patients who developed end-stage renal disease (ESRD) during 5-10
years for reasons other than progressive bilateral WT

- Matched control patients who had not developed ESRD by the time (since WT onset)
of ESRD diagnosis

- Blood and tumor tissue samples available

PATIENT CHARACTERISTICS:

- Not specified

PRIOR CONCURRENT THERAPY:

- Not specified

Type of Study:

Observational

Study Design:

N/A

Outcome Measure:

Higher incidence of ESRD in non-syndromic WT patients with germline WT1 mutations than WT patients without WT1 mutations

Safety Issue:

No

Principal Investigator

Vicki Huff, PhD

Investigator Role:

Principal Investigator

Investigator Affiliation:

M.D. Anderson Cancer Center

Authority:

United States: Federal Government

Study ID:

CDR0000696915

NCT ID:

NCT01314391

Start Date:

August 2011

Completion Date:

Related Keywords:

  • Kidney Cancer
  • Renal Failure
  • stage I Wilms tumor
  • stage II Wilms tumor
  • stage III Wilms tumor
  • stage IV Wilms tumor
  • stage V Wilms tumor
  • renal failure
  • Carcinoma, Renal Cell
  • Kidney Neoplasms
  • Wilms Tumor
  • Renal Insufficiency

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