Inclusion Criteria:

- 3.1 Conditions for Patient Eligibility 3.1.1 Pathologically (histologically) proven
diagnosis of squamous cell carcinoma (including variants such as verrucous carcinoma,
spindle cell carcinoma, carcinoma NOS, etc.) of the head/neck (oral cavity,
oropharynx or larynx); Note: Hypopharynx primaries are excluded because these
patients have both a poor prognosis and high likelihood of post-radiation
complications.

3.1.2 Clinical stage T1, N1-2 or T2-3, N0-2, M0 including no distant metastases, based
upon the following minimum diagnostic workup: 3.1.2.1 General history and physical
examination by a Radiation Oncologist and/or Medical Oncologist within 8 weeks prior to
registration; 3.1.2.2 Examination by an ENT or Head & Neck Surgeon, including
laryngopharyngoscopy (mirror and/or fiberoptic and/or direct procedure), within 8 weeks
prior to registration; 3.1.2.3 Chest x-ray (at a minimum) or chest CT scan (with or
without contrast) or CT/PET of chest (with or without contrast) within 8 weeks prior to
registration. 3.1.3 Gross total resection of the primary tumor with curative intent must
be completed within 7 weeks of registration with surgical pathology demonstrating one or
more of the following "intermediate" risk factors: 3.1.3.1 Perineural invasion; 3.1.3.2
Lymphovascular invasion; 3.1.3.3 Single lymph node > 3 cm or ≥ 2 lymph nodes (all < 6 cm)
[no extracapsular extension]; 3.1.3.4 Close margin(s) of resection, defined as cancer
extending to within 5 mm of a surgical margin; 3.1.3.5 T3 or microscopic T4a primary tumor
(Note: Gross T4a or T4b is ineligible); 3.1.3.6 T2 oral cavity cancer with > 5 mm depth of
invasion. 3.1.4 Zubrod Performance Status of 0-1 within 2 weeks prior to registration;
3.1.5 Age ≥ 18; 3.1.6 CBC/differential obtained within 4 weeks prior to registration on
study, with adequate bone marrow function defined as follows: 3.1.6.1 Absolute granulocyte
count (AGC) ≥ 1,500 cells/mm3; 3.1.6.2 Platelets ≥ 100,000 cells/mm3; RTOG 0920 18 3.1.6.3
Hemoglobin ≥ 8.0 g/dl (Note: The use of transfusion or other intervention to achieve Hgb ≥
8.0 g/dl is acceptable). 3.1.7 Adequate hepatic function, defined as follows: 3.1.7.1
Total bilirubin < 2 x institutional ULN within 2 weeks prior to registration; 3.1.7.2 AST
or ALT < 3 x institutional ULN within 2 weeks prior to registration.

3.1.8 Adequate renal function, defined as follows: 3.1.8.1 Serum creatinine < 2 x
institutional ULN within 2 weeks prior to registration or; creatinine clearance (CC) ≥ 50
ml/min within 2 weeks prior to registration determined by 24- hour collection or estimated
by Cockcroft-Gault formula: CCr male = [(140 - age) x (wt in kg)] [(Serum Cr mg/dl) x
(72)] CCr female = 0.85 x (CrCl male) 3.1.9 Negative serum pregnancy test within 2 weeks
prior to registration for women of childbearing potential; 3.1.10 (6/4/10) The following
assessments are required within 2 weeks prior to the start of registration: Na, K, Cl,
glucose, Ca, Mg, and albumin. Note: Patients with an initial magnesium < 0.5 mmol/L (1.2
mg/dl) may receive corrective magnesium supplementation but should continue to receive
either prophylactic weekly infusion of magnesium and/or oral magnesium supplementation
(e.g., magnesium oxide) at the investigator's discretion. 3.1.11 Women of childbearing
potential and male participants who are sexually active must agree to use a medically
effective means of birth control; 3.1.12 Patients must provide study specific informed
consent prior to study entry, including consent for mandatory tissue submission for EGFR
and for oropharyngeal patients, HPV analyses.

Exclusion Criteria:

- 3.2.1 Prior invasive malignancy (except non-melanomatous skin cancer) unless disease
free for a minimum of 3 years; noninvasive cancers (For example, carcinoma in situ of
the breast, oral cavity, or cervix are all permissible) are permitted even if
diagnosed and treated < 3 years ago.

Patients with simultaneous primaries or bilateral tumors are excluded. 3.2.2 Per the
operative report, positive margin(s) [defined as tumor present at the cut or inked edge of
the tumor], nodal extracapsular extension, and/or gross residual disease after surgery;
3.2.3 Prior systemic chemotherapy or anti-EGF therapy for the study cancer; note: prior
chemotherapy or anti-EGF therapy for a different cancer is allowable. See section 3.2.1.

3.2.4 Prior radiotherapy to the region of the study cancer that would result in overlap of
radiation therapy fields; 3.2.5 Severe, active co-morbidity, defined as follows: 3.2.5.1
Unstable angina and/or congestive heart failure requiring hospitalization within 6 months
prior to registration; 3.2.5.2 Transmural myocardial infarction within 6 months prior to
registration; 3.2.5.3 Acute bacterial or fungal infection requiring intravenous
antibiotics at the time of registration; 3.2.5.4 Chronic Obstructive Pulmonary Disease
exacerbation or other respiratory illness requiring hospitalization or precluding study
therapy at the time of registration; 3.2.5.5 Idiopathic pulmonary fibrosis or other severe
interstitial lung disease that requires oxygen therapy or is thought to require oxygen
therapy within 1 year prior to registration; 3.2.5.6 Hepatic insufficiency resulting in
clinical jaundice and/or coagulation defects; note, however, that laboratory tests for
coagulation parameters are not required for entry into this protocol.

3.2.5.7 Acquired Immune Deficiency Syndrome (AIDS) based upon current CDC definition;
note: HIV testing is not required for entry into this protocol. The need to exclude
patients with AIDS from this protocol is necessary because the treatments involved in this
protocol may be significantly immunosuppressive. Protocol-specific requirements may also
exclude immuno-compromised patients. 3.2.5.8 (6/4/10) Grade 3-4 electrolyte abnormalities
(CTCAE, v. 4.0):