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Airway Epithelium Gene Expression in the Diagnosis of Lung Cancer: AEGIS I

21 Years
Open (Enrolling)
Lung Cancer

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Trial Information

Airway Epithelium Gene Expression in the Diagnosis of Lung Cancer: AEGIS I

Inclusion Criteria:

1. The patient is being evaluated for the diagnosis of possible lung cancer or "rule out
lung cancer" and is indicated for bronchoscopy.

2. The patient is undergoing bronchoscopy

3. ≥ 21 years of age

4. Patient meets local site's standard of care (SOC) for performing diagnostic

5. The patient is a current or former cigarette smoker (defined as having smoked >100
cigarettes in their lifetime.

Exclusion Criteria:

1. The Pulmonary physician does not recommend that bronchoscopy be performed

2. The patient is unable to be consented into the study or unable to comply with
requirements of the study

3. The patient has previously been diagnosed with primary lung cancer

4. Immediately prior to bronchoscopy, the patient has been on a mechanical ventilator
for ≥ 24 consecutive hours.

Type of Study:


Study Design:

Observational Model: Cohort, Time Perspective: Prospective

Outcome Measure:

Primary Lung Cancer

Outcome Time Frame:

One year from enrollment

Safety Issue:


Principal Investigator

Duncan Whitney, PhD

Investigator Role:

Study Director

Investigator Affiliation:

Allegro Diagnostics


United States: Federal Government

Study ID:

ADx-0001: AEGIS I



Start Date:

January 2009

Completion Date:

May 2013

Related Keywords:

  • Lung Cancer
  • Gene Expression
  • Lung Cancer
  • Smoking
  • Lung Neoplasms



University of Alabama Birmingham, Alabama  
Beth Israel Deaconess Medical Center Boston, Massachusetts  02215
University of Missouri Columbia, Missouri  65212
Temple University Philadelphia, Pennsylvania  19140
University of Virginia Charlottesville, Virginia  22908
Columbia University New York, New York  10032-3784
Vanderbilt University Nashville, Tennessee  37232-6305
University of Pennsylvania Philadelphia, Pennsylvania  19104
New York University New York, New York  10016
Indiana University Indianapolis, Indiana  46202
LSU New Orleans, Louisiana  70112
Georgia Lung Associates Austell, Georgia  30106