Inclusion Criteria:

- Adult patients, >/=18 years of age

- Histologically confirmed glioblastoma

- Radiographic demonstration of disease progression by Response Assessment in
Neurooncology (RANO) criteria following prior therapy

- Availability of at least 1 formalin-fixed paraffin-embedded tumor tissue sample

- If receiving corticosteroids, patients must have been on a stable or decreasing dose
of corticosteroids

- Prior standard radiotherapy for glioblastoma

- Karnofsky Performance status >/=70

- Over 4 weeks since prior surgical resection

- Over 12 weeks from radiotherapy

- Over 4 weeks from anticancer agents

Exclusion Criteria:

- Patients had second or later glioblastoma relapse

- Patients received more than one systemic treatment regimen for glioblastoma

- Patients have secondary glioblastoma

- Prior treatment with Avastin

- Patients unable to undergo Magnetic Resonance Imaging (MRI)