Inclusion Criteria:

- Postmenopausal women defined as a woman who has stopped having menstrual periods

- Breast Cancer has continued to grow after having received treatment with an
anti-estrogen hormonal treatment such as tamoxifen or an aromatase inhibitor

- Requiring hormonal treatment

- Oestrogen-receptor positive tumour

- Written informed consent to participate in the trial

Exclusion Criteria:

- Treatment with an investigational or non-approved drug within one month

- An existing serious disease, illness, or condition that will prevent participation or
compliance with study procedures

- A history of allergies to any active or inactive ingredients of fulvestrant (i.e.
castor oil)

- Treatment with more than one regimen of chemotherapy for advanced breast cancer

- Treatment with more than one regimen of hormonal treatment for advanced breast cancer