Biological Correlates With T-cell Acute Lymphoblastic Leukemia (T-ALL) Gene Expression and Clinical Outcome
OBJECTIVES:
- To confirm an association between induction failure (IF) status predicted by a
previously identified 116-member genomic classifier and actual induction therapy
outcome observed on COG study AALL0434.
- To explore whether there is an association between early relapse (as defined by bone
marrow or extramedullary relapse within 18 months of diagnosis) predicted by previously
identified 5-member (primary) and 57-member (secondary) genomic classifiers, and actual
relapse status at 18 months on COG study AALL0434. (Exploratory)
OUTLINE: RNA from cryopreserved bone marrow samples are analyzed for gene expression by
microarray methods. Samples are then compared with the 116-member genomic classifier.
Observational
N/A
Association between induction failure status predicted by 116-member genomic classifier and actual induction therapy outcome observed on COG study AALL0434
No
Stuart S. Winter, MD
Principal Investigator
University of New Mexico Cancer Center
United States: Federal Government
CDR0000695252
NCT01295476
April 2011
Name | Location |
---|