Inclusion Criteria:

- Adult patients, >/=18 years of age

- Patients with treatment-requiring chronic lymphocytic leukemia (CLL)

- Eastern Cooperative Oncology Group (ECOG) performance status of 0-1

- Life expectancy >6 months

Exclusion Criteria:

- Transformation to aggressive B-cell malignancy

- History of other malignancy unless the patient was treated with curative intent and
has been in remission for more than 5 years prior to enrolment

- HIV or Hepatitis B positive

- Inadequate liver or renal function

- Any coexisting medical or psychological condition that would preclude participation
in the required study procedures

Additional exclusion criterion for Part 1:

- Any previous treatment for CLL except for up to 4 cycles of rituximab iv in
combination with FC chemotherapy as first-line treatment for CLL

Additional exclusion criterion for Part 2:

Any previous treatment for CLL