Observational Study Aimed to Characterize a System for Breast and Colon Cancer Diagnosis by Breath Testing - NaNose Study
Cancer is accompanied by increased oxidative stress and induction of polymorphic cytochrome
P- 450 mixed oxidase enzymes (CYP). Both processes affect the abundance of volatile organic
compounds (VOCs) in the breath because oxidative stress causes lipid peroxidation of
polyunsaturated fatty acids in membranes, producing alkanes and methylalkanes which are
catabolized by CYP.
In the Technion labs, a new system for breath samples diagnosis, is being developed. The
system is based on Nanoparticles technology.
The current study will try to identify colon and breast cancer patients through their breath
samples and discriminate them from healthy individuals.
Men and women coming for colonoscopy or breast biopsy will be recruited for the study.
Breath samples will be taken from all volunteers before the medical test. Subjects with
positive cancer results by biopsy will be the test groups for both diseases, all others will
be the control.
The research goal is to test the NaNose system ability to discriminate between healthy and
Observational Model: Case Control, Time Perspective: Prospective
Sensitivity and specificity of NaNose system in diagnosing cancer
Israel: Ministry of Health