Inclusion Criteria:

- Histologically or cytologically proven non small cell lung cancer

- Stage IV (M1a or M1b) disease. Patients may also have recurrence of early-stage
disease or locally advanced disease with the presence of new distant metastases.

- Cyclin dependent kinase (CDK)N2a (p16) protein absent or expressed at a low level in
tumor biopsy specimen

- Failed or intolerant of at least one prior systemic chemotherapy regimen (there is no
maximum number of prior chemotherapy regimens)

- Eastern cooperative oncology group (ECOG) performance status 0-2

- Age >18 years.

- Adequate organ and bone marrow function

- Measurable disease by standard RECIST v1.1 criteria

- Life expectancy of greater than 3 months

Exclusion Criteria:

- Inability to understand or sign the informed consent document

- Inability or unwillingness to take oral medications

- No available tissue specimen for p16 analysis

- Chemotherapy or radiotherapy within 3 weeks prior to beginning the study drug

- Other investigational agents within 4 weeks prior to beginning the study drug

- All side effects from previous chemotherapy, radiotherapy or investigational agents
not resolved, returned to baseline or returned to Grade 1 toxicity (exceptions are
grade 2 alopecia and grade 2 peripheral neuropathy)

- Major surgery within 4 weeks prior to beginning the study drug

- Surgical scar from previous surgery not healed prior to beginning the study drug

- High-dose or chronic steroid use

- High-dose statins within 7 days

- History of rhabdomyolysis

- Uncontrolled intercurrent illness including, but not limited to, ongoing or active
infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac
arrhythmia, uncontrolled diabetes, stroke or myocardial infarction within 3 months,
or psychiatric illness/social situations that would limit compliance with study
requirements.

- Baseline corrected QT interval (QTc) >470ms

- Pre-existing clinically significant cardiac, hepatic or renal dysfunction at the
discretion of the treating physician

- Untreated or uncontrolled (symptomatic or asymptomatic) brain metastases

- Leptomeningeal carcinomatosis

- Inability or unwillingness to use contraception during the treatment period by
patients with reproductive potential.

- Pregnant or breastfeeding women

- HIV-positive patients on combination antiretroviral therapy