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KIR Genotyping for Unrelated Donor (URD) Selection Prior to Hematopoietic Cell Transplantation (HCT) for AML: Selecting a Favorable KIR Donor

Open (Enrolling)
Acute Myelogenous Leukemia

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Trial Information

KIR Genotyping for Unrelated Donor (URD) Selection Prior to Hematopoietic Cell Transplantation (HCT) for AML: Selecting a Favorable KIR Donor

Transplant Centers will select the best HLA matched, and as appropriate, preferred KIR

Inclusion Criteria:

- Patient with acute myeloid leukemia (AML) undergoing screening for potential URD HCT

- Potential URD undergoing screening to provide a HCT graft to a patient with acute
myeloid leukemia (AML) at a participating institution

- Provides written consent

Type of Study:


Study Design:

Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Outcome Measure:

Incidence of Relapse

Outcome Description:

To measure the impact of donor selection for KIR genotype in allogeneic URD HCT for AML on cumulative incidence of relapse. We will determine a quantitative estimate of the likelihood of better KIR donors identified with routine, non-directed donor selection along with KIR genotyping data. The observed incidence of success in a better KIR donor identified within 8 weeks will be compared to the original donor genotype expected frequencies identified in our retrospective genotyping of 1086 donors selected for AML transplants.

Outcome Time Frame:

2 Years

Safety Issue:


Principal Investigator

Daniel Weisdorf, M.D.

Investigator Role:

Principal Investigator

Investigator Affiliation:

Masonic Cancer Center, University of Minnesota


United States: Institutional Review Board

Study ID:




Start Date:

March 2011

Completion Date:

August 2014

Related Keywords:

  • Acute Myelogenous Leukemia
  • acute myelogenous leukemia
  • hematopoietic cell transplantation
  • unrelated donor
  • Leukemia
  • Leukemia, Myeloid, Acute
  • Leukemia, Myeloid



Roswell Park Cancer InstituteBuffalo, New York  14263
Fred Hutchinson Cancer Research CenterSeattle, Washington  98109
Mayo Clinic Cancer CenterRochester, Minnesota  55905
Washington University School of MedicineSaint Louis, Missouri  63110
Hackensack University Medical CenterHackensack, New Jersey  07601
University of PennsylvaniaPhiladelphia, Pennsylvania  19104
Emory UniversityAtlanta, Georgia  30322
Cleveland ClinicCleveland, Ohio  44195
M.D. Anderson Cancer CenterHouston, Texas  77030
Masonic Cancer Center, University of MinnesotaMinneapolis, Minnesota  55455
Indiana University Simon Cancer CenterIndianapolis, Indiana  46202
Baylor Sammons Cancer CenterDallas, Texas  75246
Mayo Clinic - ScottsdaleScottsdale, Arizona  85259
Colorado Blood Cancer InstituteDenver, Colorado  80218
Ohio State University Comprehensive Cancer CenterColumbus, Ohio  
Kansas University Cancer CenterKansas City, Kansas  66160
New York Presbyterian Weill Cornell Medical CenterNew York, New York  10021
University of Chicago Medical Center Cancer CenterChicago, Illinois  60637
Methodist Healthcare System of San AntonioSan Antonio, Texas  78229