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Academia Sinica Investigator Award 2010

20 Years
Open (Enrolling)
Breast Cancer

Thank you

Trial Information

Academia Sinica Investigator Award 2010

Ji-Hong Jhu (朱紀洪, Hospital President, M.D./surgeon) and Huey-Kong Sytwu (司徒惠康, M.D., Ph.D.)
at the National Defense University Hospital. The investigators will then study the molecular
signaling effect of specific phytocompounds already identified to confer in vivo (mouse),
anti-tumor and anti-inflammatory activities, in primary/organoid cultures of human breast
tumor cells under ex vivo conditions. Finally, the investigators intend to identify the key
molecular regulators, immune-modulatory effectors of test stromal immune cells that are
affected by the candidate phytomedicines, using molecular and cell biology assays to
investigate the interplay between immune cells and tumor cells in the stromal tissues.

Our study is expected to reveal one or more highly specific, anti-inflammatory
phytocompounds that mechanistically confer specific effects on stromal fibroblast or immune
cell types, resulting in potent anti-tumor effects on test mammary carcinoma systems. Five
Specific Aims are thus designed to investigate the immuno-modulating effects of specific
medicinal constituents from TCM materials. The experimental findings obtained from this
study would provide insights in the molecular, cellular and signaling mechanisms/effects of
several medicinal phytocompounds that may have potential applications in chemoprevention or
herbal medicine adjuvant treatment of human breast cancers.

Inclusion Criteria:

- adult

- breast cancer patient

- had signed the consent agreement, after your surgery, we will collect the sample from
surgically removed breast tissue.

Exclusion Criteria:

- pregnancies

- minor children

- teenagers

- neonates

Type of Study:


Study Design:

Time Perspective: Prospective

Principal Investigator

Ning-Sun Yang

Investigator Role:

Principal Investigator

Investigator Affiliation:

Academia Sinica


Taiwan: Department of Health

Study ID:




Start Date:

June 2010

Completion Date:

December 2014

Related Keywords:

  • Breast Cancer
  • phytomedicines
  • breast cancer
  • stromal fibroblasts
  • MDSCs
  • functional mechanism
  • Breast Neoplasms