Inclusion Criteria

Inclusion

- Patients must have a histologically or cytologically confirmed adenocarcinoma of the
colon or rectum that is metastatic to the liver and for which standard curative
measures do not exist

- Patients must have received prior irinotecan-based treatment for their disease and
had documented progression by RECIST criteria; patients must also have received prior
fluoropyrimidine and oxaliplatin-based therapy

- Liver disease must not be amenable to potentially curative surgical resection

- Patients must have liver-only or liver-predominant disease to be eligible for this
study; hepatic disease must be dominant, but patients are allowed to have
extrahepatic disease provided it is not judged likely to be life threatening within 3
months

- Patients must have a patent portal vein as documented by CT, MRI, or ultrasound

- Prior radiation therapy is allowed but must have been completed >= 4 weeks prior to
study entry; patients with history of prior radiation to the liver including
radio-labeled microspheres cannot take part in this study

- Eastern Cooperative Oncology Group performance status 0-1

- Previous surgery or RFA to the liver is allowed; patients with history of
chemoembolization or radio-labeled microspheres are excluded

- Life expectancy of >= 12 weeks

- Leukocytes >= 3,000/uL

- Absolute neutrophil count >= 1,500/uL

- Platelets >= 100,000/uL

- Total bilirubin =< ULN

- AST(SGOT)/ALT(SGPT)/Alkaline Phosphatase =< 2.5 X institutional ULN

- Creatinine < 2.0 mg/dL

- PT/PTT < 1.5 X ULN

- Women of childbearing potential (WOCBP) and sexually active males must agree to use
an accepted and effective method of contraception prior to study entry and for the
duration of the study; WOCBP include any female who has experienced menarche and who
has not undergone successful surgical sterilization (hysterectomy, bilateral tubal
ligation or bilateral oophorectomy) or is not postmenopausal; even women who are
using oral, implanted or injectable contraceptive hormones or mechanical products
such as an intrauterine device or barrier methods (diaphragm, condoms, spermicides)
to prevent pregnancy or practicing abstinence or where partner is sterile (e.g.,
vasectomy) should be considered to be of child bearing potential

- Patients must demonstrate ability to understand and the willingness to sign a written
informed consent document

Exclusion

- Patients who have had chemotherapy (including targeted therapy i.e. cetuximab,
panitumumab) or radiotherapy =< 4 weeks or treatment with bevacizumab =< 6 weeks
prior to entering the study or those who have not recovered from acute adverse events
due to agents administered more than 4 weeks earlier, with the exclusion of alopecia
or neuropathy; patient with history of radiation to the liver including radio-labeled
microspheres at any point in their past will be excluded

- Patients may not be receiving nor have received any other investigational agent =< 4
weeks prior to study registration

- Pregnant or nursing women may not participate in this trial because of the increased
risk of fetal harm including death from the therapeutic agents

- Patients with known brain metastases are excluded from this study because of their
poor prognosis and frequent development of progressive neurological dysfunction that
would confound the evaluation of neurologic and other adverse events

- As patients with immune deficiency are at increased risk of lethal infections when
treated with marrow-suppressive therapy, known HIV-positive patients and those with
known hepatitis B or C are excluded from the study

- Uncontrolled intercurrent illness including, but not limited to, ongoing or active
bacterial infection, symptomatic congestive heart failure, unstable angina pectoris,
cardiac arrhythmia, or psychiatric illness/social situations that would limit
compliance with study requirements

- Patients with clinically evident ascites requiring medical management or
paracentesis, or Childs-Pugh score B/C are not eligible

- Patients with evidence of other cancer within 5 years, excluding adequately treated
basal cell carcinoma of the skin

- Patient with significant cardiac, renal or hematologic or pulmonary dysfunction

- Patients with previous chemoembolization to liver metastases

- Patients may not receive any other anticancer therapy while on study, including
immunotherapy; patients may not receive any other clinical investigational drug