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The Use of Major Depression Inventory (MDI) in Measuring Preoperative Depressive Symptoms in Breast Cancer Patients

30 Years
70 Years
Not Enrolling
Depression, Depressive Symptoms

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Trial Information

The Use of Major Depression Inventory (MDI) in Measuring Preoperative Depressive Symptoms in Breast Cancer Patients

The Major Depression Inventory is a self-rating depression scale with 12 questions. The
questionnaire has previously been investigated in a Danish population. The scale contains
the 10 ICD-10 (International Classification of Diseases)symptoms of depression and these
symptoms are identical with the DSM-IV major depression symptoms with the exception of one
symptom, low self-esteem, which in DSM-IV (Diagnostic and Statistical Manual of Mental
Disorders) is incorporated in the symptom of guilt. On a six-point Likert scale, the
individual items measure how much of the time the symptoms have been present during the last
14 days. The MDI is then scored according to specific guidelines and can be used as both a
rating scale and a diagnostic instrument.

Patients will approximately one week after the diagnosis of breast cancer has been made,
corresponding to approximately one week before surgery, be asked to complete the MDI.
Patients therefore only complete the MDI once in the whole study. At the same time a Mini
Mental State Examination (MMSE) and questions regarding previous illnesses and medication
will be asked. Patients will not be followed up in any way.

Inclusion Criteria:

- Women aged 30-70 years old, who are undergoing a lumpectomy or mastectomy


Exclusion Criteria:

- Planned or ongoing preoperative chemotherapy

- Known and treated sleep apnea syndrome

- Insulin treated diabetes mellitus

- Known or previous treated depressive illness or bipolar disorder

- Known autoimmune disease

- Incompensated cirrhosis

- Other previous or ongoing cancer

- Known medically treated sleep disorder (insomnia, restless legs etc)

- Shift-work or night-work

- Daily alcohol intake of more than 5 units

- Preoperative treatment with psychopharmacological drugs, opioids or anxiolytics

- Predicted bad compliance

- Pregnant or breast feeding

- Preoperative MMSE score less than 24

Type of Study:


Study Design:

Observational Model: Cohort, Time Perspective: Cross-Sectional

Outcome Measure:

Depressive symptoms

Outcome Description:

Total score on the Major Depression Inventory. When used as a diagnostic instruemtn patients witll according to the ICD-10 algorhythym be classified as mild, moderate or severe depression or no depression.

Outcome Time Frame:

Approximately one week before surgery

Safety Issue:


Principal Investigator

Melissa V Hansen, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Herlev Hospital


Denmark: The Danish National Committee on Biomedical Research Ethics

Study ID:




Start Date:

January 2011

Completion Date:

March 2011

Related Keywords:

  • Depression
  • Depressive Symptoms
  • Breast Neoplasms
  • Depression
  • Depressive Disorder
  • Depressive Disorder, Major