Prospective Observational Study Of Patients With Asymptomatic Centrally Located Advanced NSCLC Who Are Not Suitable For Curative Treatment
Inclusion Criteria:
- Histologically or cytologically confirmed NSCLC
- Central disease, as defined by tumour (either primary or nodal disease) arising or
extending within a 2cm circumferential expansion from the centre of the trachea or
within the zone of the proximal bronchial tree
- Disease is visible on thoracic CT (diagnostic or simulation)
- Asymptomatic from intra-thoracic tumour (may have background chest symptoms related
to underlying COAD etc, but these symptoms must not have worsened due to tumour)
- Patient (due to age or co-morbidities) or tumour (due to locally advanced or
metastatic disease) is not suitable for radical treatment (defined as surgery or RT
dose >50Gy in 20 fractions or equivalent).
- Previous chemotherapy, thoracic RT or surgery is allowed
- RT to other metastases (e.g. brain, bone etc) is allowed
•≥ 18 years of age
- Able to provide written informed consent
Exclusion Criteria:
- Intra-thoracic disease is peripheral only, not extending within 2cm of
trachea/proximal bronchial tree
- Symptomatic from intra-thoracic NSCLC
- Histological diagnosis of small cell lung cancer, or malignant mediastinal
lymphadenopathy from another malignancy (not NSCLC)