'The Factors Associated With the Formation of Nasal Polyp'
The present study involves two parts. A case control study wherein the association of nasal
polyps with various risk factors like smoking, wood stove exposure, allergic rhinitis, non
vegetarian diet intake, rhino sinusitis, deviated nasal septum, occupational dust exposure
and eosinophilia.This will be studied individually for antrochoanal and ethmoidal nasal
polyps.Again the same will be studied with respect to the recurrent and non recurrent
A descriptive study focuses on the nasal polyp occurrence with respect to the age, sex,
religion, socioeconomic status, urban or rural preponderance,overcrowding, aspirin
intolerance, family history etc.
The results will be studies after calculating the odds ratio and the chi square test for
whatever data is available. Interpretation will be performed subsequently.
Gene expression profiling would be performed to study the differences in gene expression
levels between AC and EP s with respect to risk factors and morphological
characteristics.Mutational analysis will be performed to identify mutations in selected
Observational Model: Case Control, Time Perspective: Prospective
Association of the antrochoanal and ethmoidal polyps with smoking, wood stove exposure, allergic rhinitis, deviated nasal septum, rhino sinusitis, non vegetarian diet,eosinophilia and staphylococcus aureus in terms of the odds ratio.
Based on the questionnaire the patient will be evaluated for the presence of risk factors. Patient will be subjected to appropriate investigations like complete hemogram, absolute eosinophil count, contrast tomography scan of the paransal sinuses and serum IgE levels will be performed.An odds ratio will be calculated after taking appropriate controls in the ratio of 2:1.Significance levels will be calculated using Chi square test.
Dr.Manjunath D Narasaiah, MS
Assistant Professor in ENT, Karnataka Institute of Medical Sciences, Hubli-580021, Karnataka, India
India: Institutional research regulatory committee