Food and Health; Testing of the Anti-Inflammatory Potential of a Macronutrient Balanced Normocaloric Diet
The hypothesis of this proposal is that a carbohydrate-rich diet may cause a major
deregulation of hormonal balance, causing both acute and chronic systemic inflammatory
reactions mediated by white blood cells. We furthermore postulate that a carbohydrate-rich
diet is an underexplored major risk factor in the development of obesity and life style
diseases directly resulting from chronic systemic inflammation. We therefore want to use an
integrated multidisciplinary systems biology approach to identify the hormones, genes and
pathways specifically responding to a dietary carbohydrate reduction, to develop biomarkers
that can be used for risk assessment, to identify molecular pathways and build mathematical
models that describe the link between diet and inflammation, and use this knowledge to
provide personalised dietary advice.
Interventional
Allocation: Non-Randomized, Intervention Model: Factorial Assignment, Masking: Open Label, Primary Purpose: Treatment
Changes in microarray gene expression
Changes in microarray gene expression profiles in blood from morbid obese women, in response to balanced dietary macro nutrient composition
Day 1, 4 and 14
No
Berit Johansen, PhD
Principal Investigator
Norwegian University of Science and Technology
Norway: Regional Ethics Commitee
2010.1122.3
NCT01278121
February 2011
January 2012
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