Inclusion Criteria:

- Age olderthan 21

- A Patient on chemotherapy who was diagnosed malignant tumor

- A Patient who is newly developed hiccup in the course of chemotherapy

- A patient with the willingness to comply with the study protocol during the study
period and capable of ccomplying with it

- A patient who signed the imformed consent prior to the participation of the study and
who understands that he/she has a right to withdrawal from participation in the study
at any time without any disadvantages

Exclusion Criteria:

- A patient with history of uncontrolled seizures, central nervous system disorder or
psychiatric disorders that are considered clinically significant by the investigator
that would prohibit the understanding of informed consent or that may be considered
to interfere with the compliance of the administration of the study medications

- A patient with uncontrolled diabetes

- A patient who developed uncontrolled serious infection or other uncontrolled serious
concomitant diseases

- A patient with disease progression after run-in period who is expected to receive
another chomotherapeutic agents with different level of emetic risk