Trial Information

Pilot Study of Secondary Causes of Osteopenia/Osteoporosis in Adults With Breast and Prostate Cancer

The interaction of aging, cancer, and bone loss is poorly understood. Cancer or cancer
therapy could potentially accelerate bone loss and increase the risk for osteopenia or
osteoporosis. The hypothesis of this observational study is that secondary causes of bone
loss are prevalent in patients with breast and prostate cancer who are high risk for
treatment related bone loss. In order to test this hypothesis, this prospective pilot study
will systematically evaluate secondary causes of bone loss in a cohort of patients with
nonmetastatic breast and prostate cancer with osteopenia/osteoporosis.

1. Identify patients with nonmetastatic breast cancer newly diagnosed with
osteopenia/osteoporosis (Dual Energy X-ray Absorptiometry Bone Density scan T-score
average between hip (femoral neck) and spine (L1-L4) of less than -1.0 to -2.5/ less
than -2.5, respectively).

2. Identify patients with nonmetastatic prostate cancer newly diagnosed with
osteopenia/osteoporosis (Dual Energy X-ray Absorptiometry Bone Density scan T-score
average between hip (femoral neck) and spine (L1-L4) of less than -1.0 to -2.5/ less
than -2.5, respectively).

3. Refer patient to City of Hope Endocrinology Osteoporosis Clinic.

4. Approach patient in consecutive order in which they have been referred to Endocrinology
Osteoporosis Clinic.

5. Describe the study to the patient: patient consents or refuses.

6. Once consented, the patient's medical records are reviewed and Dual Energy X-ray
Absorptiometry Bone Density reports are obtained from City of Hope records or the
screening medical institution records to confirm diagnosis of osteopenia/osteoporosis
or normal bone health.

7. Study participants will undergo an evaluation for secondary causes of bone per standard
of care with patient questionnaires.

8. Furthermore, laboratory tests that support secondary causes of bone loss will be
retrospectively collected via chart review.