Inclusion Criteria:

- Non lobular epithelial breast carcinoma, excised with standard quadrantectomy

- Age ≥ 45 and < 85

- Tumor major diameter ≤ 2.5 cm

- Negative surgical margins (≥ 5 mm)

- Willingness to undergo follow up examinations

- Willingness to undergo imaging examinations (MRI, mammograms, ultrasonography)

- Signed informed consent

Exclusion Criteria:

- Ductal carcinoma in situ or lobular carcinoma

- Extensive intraductal component (greater than 25%) or intraductal carcinoma with
microinvasion

- Serious concomitant disease or any disorder or condition (such as psychiatric or
addictive disorders) that, in the opinion of the investigator, would preclude the
patient from meeting the study requirements

- Pregnancy or lactation at the time of enrolment proposal (if necessary, during the
trial patients must use effective contraceptive device)

- Collagen vascular disorders