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A Phase III Randomized Study of Adjuvant Ipilimumab Anti-CTLA4 Therapy Versus High-Dose Interferon Alpha-2b for Resected High-Risk Melanoma


Phase 3
18 Years
N/A
Open (Enrolling)
Both
Recurrent Melanoma, Stage IIIB Melanoma, Stage IIIC Melanoma, Stage IV Melanoma

Thank you

Trial Information

A Phase III Randomized Study of Adjuvant Ipilimumab Anti-CTLA4 Therapy Versus High-Dose Interferon Alpha-2b for Resected High-Risk Melanoma


PRIMARY OBJECTIVES:

I. To evaluate recurrence-free survival (RFS) between patients randomized to receive
post-operative adjuvant ipilimumab given at either 10 mg/kg (high dose ipilimumab; HIP) or 3
mg/kg (low dose ipilimumab: LIP) versus those randomized to receive HDI utilizing a
hierarchical design assessing HIP versus HDI first and LIP versus HDI second (if the first
comparison is significant).

II. To evaluate overall survival (OS) between patients randomized to receive post-operative
adjuvant ipilimumab given at either 10 mg/kg (HIP) or 3 mg/kg (LIP) versus those randomized
to receive HDI utilizing a hierarchical design assessing HIP versus HDI first and LIP versus
HDI second (if the first comparison is significant).

SECONDARY OBJECTIVES:

I. To evaluate safety and tolerability of post-operative adjuvant ipilimumab therapy given
at either 10 mg/kg (HIP) or 3 mg/kg (LIP).

II. Among patients enrolled by CCOPs, to compare the global QOL between the ipilimumab arms
versus HDI using FACT-G form and to evaluate the effect of treatment-related side effects
that may have an impact on the health-related domains of QOL using FACIT-D and FACT-BRM.

OUTLINE: Patients are randomized to 1 of 2 treatment arms.

ARM I: Patients receive induction ipilimumab IV over 90 minutes on day 1. Treatment repeats
every 21 days for a total of 4 courses in the absence of disease progression or unacceptable
toxicity. Beginning on week 24, patients receive maintenance ipilimumab IV over 90 minutes
on day 1. Treatment repeats every 90 days for a maximum of 4 courses in the absence of
disease progression or unacceptable toxicity.

ARM II: Patients receive induction high-dose recombinant interferon alfa-2b IV on days 1-5,
8-12, 15-19, and 22-26 in the absence of disease progression or unacceptable toxicity.
Patients then receive maintenance high-dose recombinant interferon alfa-2b subcutaneously on
days 1, 3, and 5. Treatment repeats every week for 48 weeks in the absence of disease
progression or unacceptable toxicity.

After completion of study therapy, patients are followed up every 3 months for 2 years,
every 6 months for 3 years, and then yearly for 15 years.


Inclusion Criteria:



- Diagnosis of melanoma of a cutaneous origin or unknown primary

- No ocular melanoma or melanoma of mucosal origin

- Stage IIIB, IIIC, or IV (M1a or M1b) disease

- Patients with stage IV melanoma must have normal LDH and distant skin,
subcutaneous, lymph node, or lung metastases

- No other visceral metastases allowed

- Disease that has been completely resected with negative margins on resected specimens
within the past 12 weeks

- Disease-free status documented by a complete physical examination and imaging
studies within 4 weeks prior to randomization

- Imaging studies must include a total body PET-CT scan (with or without
brain) and brain MRI or CT (if MRI is contraindicated) (if PET-CT cannot be
done, CT scan of neck, chest, abdomen, and pelvis should be done)

- Patients rendered free of disease by non-surgical means not allowed

- Disease recurrence after adequate surgical excision of original primary cutaneous
melanoma allowed provided one of the following criteria are met:

- Recurrence in a regional lymph node basin after a prior complete lymph node
dissection

- Relapsed disease must be completely surgically resected with free margins

- Recurrence in the form of in-transit or satellite metastases or distant
skin/subcutaneous, nodal, or lung metastases that are completely surgically
resected with free margins

- Recurrence in a regional lymph node basin

- Relapsed disease must be completely surgically resected with free margins

- Patients must be randomized within 84 days (12 weeks) of surgical resection; if more
than one surgical procedure is required to render the patient disease-free, the
patient must be randomized within 12 weeks of the last surgery

- NOTE: patients with clinically positive lymph nodes for melanoma involvement or
those with positive lymph nodes identified through lymphoscintigraphic and/or
dye lymphographic techniques in the groin, axilla, or neck should have
additional lymphadenectomy in those sites; the complete lymph node dissection
procedure would be considered as the last surgery in counting the 84 days unless
a subsequent surgical procedure(s) was clinically required to ensure the disease
free status

- ECOG performance status 0-1

- WBC ≥ 3,000/μL

- ANC ≥ 1,500/μL

- Platelet count ≥ 100,000/μL

- Hemoglobin ≥ 10 g/dL

- Serum creatinine ≤ 1.8 mg/dL

- AST and ALT ≤ 2.5 times upper limit of normal (ULN)

- Serum bilirubin < 2 times ULN (< 3 mg/dL in case of Gilbert syndrome)

- Not pregnant or nursing

- Negative pregnancy test

- Fertile patients must use adequate method of contraception throughout the study and
for up to 26 weeks after the last dose of high-dose recombinant interferon alpha-2b
(HDI)

- No active infection requiring concurrent treatment with parenteral antibiotics

- None of the following:

- Other significant medical, surgical, or psychiatric conditions

- Requirement for any medication or treatment that, in the opinion of the
investigator, may interfere with compliance, make the administration of
ipilimumab or HDI hazardous, or obscure the interpretation of adverse events,
such as a condition associated with frequent diarrhea

- Patients should be carefully screened for depression at baseline and if there are
indications or a history of depression it is strongly recommended that these patients
be closely followed together with behavioral health or psychiatric medical support;
patients with an established diagnosis of depression that, in the assessment of the
investigator may make the administration of IFNα or ipilimumab hazardous, should not
be enrolled on this protocol; the risks and benefits of being treated with standard
adjuvant IFNα should be weighed very carefully in consultation with behavioral health
or psychiatry

- No documented history of inflammatory bowel disease, including ulcerative colitis and
Crohn disease, or diverticulitis

- History of diverticulosis allowed

- No autoimmune disorders or conditions of immunosuppression that require current
ongoing treatment with systemic corticosteroids (or other systemic
immunosuppressants), including oral steroids or continuous use of topical steroid
creams or ointments or ophthalmologic steroids

- History of occasional (but not continuous) use of steroid inhalers allowed

- None of the following:

- History of symptomatic autoimmune disease

- Rheumatoid arthritis

- Systemic progressive sclerosis (scleroderma)

- Systemic lupus erythematosus

- Sjögren syndrome

- Autoimmune vasculitis (e.g., Wegener granulomatosis)

- Motor neuropathy considered of autoimmune origin (e.g., Guillain-Barre syndrome
and myasthenia gravis)

- Other CNS autoimmune disease (e.g., poliomyelitis, multiple sclerosis)

- Autoimmune hypothyroid disease or type 1 diabetes allowed provided replacement
therapy is administered

- Not incarcerated or compulsorily detained (involuntarily incarcerated) for treatment
of either a psychiatric or physical (e.g., infectious) illness

- No other current malignancies except any prior in situ cancer, lobular carcinoma of
the breast in situ, cervical cancer in situ, atypical melanocytic hyperplasia or
melanoma in situ, multiple primary melanomas, basal or squamous skin cancer, or other
malignancies for which the patient has been disease free for > 5 years

- No active or chronic infection with HIV, hepatitis B virus (HBV), or hepatitis C
virus (HCV)

- Patients must have negative testing for HIV, hepatitis B antigen, and HCV within
the past 4 weeks

- No other concurrent anticancer or investigational agent

- No prior adjuvant treatment (chemotherapy, biotherapy, or limb perfusion) after
resection

- At least 30 days since prior radiotherapy, including after surgical resection

- No prior or concurrent anti-CTLA4 monoclonal antibodies, CTLA-4 inhibitor or agonist,
CD137 agonist, or prior interferon-α

- At least 4 weeks since prior aldesleukin (IL-2), anti-tumor vaccine, or chemotherapy
given before randomization

- No infectious disease vaccination (e.g., standard influenza, H1N1 influenza,
pneumococcal, meningococcal, or tetanus toxoid) within the past 4 weeks

- No concurrent systemic corticosteroids (or other systemic immunosuppressants),
including oral steroids (i.e., prednisone, dexamethasone), continuous use of topical
steroid creams or ointments, or ophthalmologic steroids

- Occasional but not continuous use of steroid inhalers allowed

- Systemic corticosteroids (or other systemic immunosuppressants), including oral
steroids (i.e., prednisone, dexamethasone), continuous use of topical steroid
creams or ointments, or ophthalmologic steroids within the past 2 weeks allowed
provided, in judgment of the treating physician investigator, that the patient
is not likely to require resumption of treatment with these classes of drugs
during the study

- Replacement doses of steroids for patients with adrenal insufficiency allowed

- No concurrent chemotherapy or radiotherapy

Type of Study:

Interventional

Study Design:

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Outcome Measure:

Recurrence-free survival

Outcome Time Frame:

Time from randomization to the time of disease recurrence or death from any cause, assessed up to 20 years

Safety Issue:

No

Principal Investigator

Ahmad Tarhini

Investigator Role:

Principal Investigator

Investigator Affiliation:

Eastern Cooperative Oncology Group

Authority:

United States: Food and Drug Administration

Study ID:

NCI-2011-02649

NCT ID:

NCT01274338

Start Date:

May 2011

Completion Date:

Related Keywords:

  • Recurrent Melanoma
  • Stage IIIB Melanoma
  • Stage IIIC Melanoma
  • Stage IV Melanoma
  • Melanoma

Name

Location

Albert Einstein College of MedicineBronx, New York  10461
Louisiana State UniversityNew Orleans, Louisiana  70112-2282
Cleveland Clinic FoundationCleveland, Ohio  44195
H. Lee Moffitt Cancer Center and Research InstituteTampa, Florida  33612
University of Iowa Hospitals and ClinicsIowa City, Iowa  52242
Washington University School of MedicineSaint Louis, Missouri  63110
Abington Memorial HospitalAbington, Pennsylvania  19001
Fox Chase Cancer CenterPhiladelphia, Pennsylvania  19111
University of Washington Medical CenterSeattle, Washington  98195-6043
Hurley Medical CenterFlint, Michigan  48503
Rhode Island HospitalProvidence, Rhode Island  02903
Sinai Hospital of BaltimoreBaltimore, Maryland  21225
Beth Israel Deaconess Medical CenterBoston, Massachusetts  02215
Boulder Community HospitalBoulder, Colorado  80301-9019
Porter Adventist HospitalDenver, Colorado  80210
Rose Medical CenterDenver, Colorado  80220
Swedish Medical CenterEnglewood, Colorado  80110
Sky Ridge Medical CenterLone Tree, Colorado  80124
North Suburban Medical CenterThornton, Colorado  80229
Genesys Hurley Cancer InstituteFlint, Michigan  48503
West Michigan Cancer CenterKalamazoo, Michigan  49007-3731
Fairview Ridges HospitalBurnsville, Minnesota  55337
Hutchinson Area Health CareHutchinson, Minnesota  55350
United HospitalSt. Paul, Minnesota  55102
Ridgeview Medical CenterWaconia, Minnesota  55387
Geisinger Medical CenterDanville, Pennsylvania  17822-0001
Abramson Cancer Center of the University of PennsylvaniaPhiladelphia, Pennsylvania  19104-4283
Avera Cancer InstituteSioux Falls, South Dakota  57105
Loyola University Medical CenterMaywood, Illinois  60153
Massachusetts General Hospital Cancer CenterBoston, Massachusetts  02114
CentraCare ClinicSaint Cloud, Minnesota  56303
Morristown Memorial HospitalMorristown, New Jersey  07962-1956
Henry Ford HospitalDetroit, Michigan  48202
Marshfield ClinicMarshfield, Wisconsin  54449
Sutter Health Western Division Cancer Research GroupGreenbrae, California  94904
Ingalls Memorial HospitalHarvey, Illinois  60426
Methodist Medical Center of IllinoisPeoria, Illinois  61636
Memorial Hospital of South BendSouth Bend, Indiana  46601
Marquette General HospitalMarquette, Michigan  49855
Beth Israel Medical CenterNew York, New York  10003
Akron General Medical CenterAkron, Ohio  44302
Lehigh Valley HospitalAllentown, Pennsylvania  18103
Reading Hospital and Medical CenterReading, Pennsylvania  19612-6052
Jackson-Madison County General HospitalJackson, Tennessee  38301
LDS HospitalSalt Lake City, Utah  84143
Virginia Mason Medical CenterSeattle, Washington  98111
Waukesha Memorial HospitalWaukesha, Wisconsin  53188
Rush University Medical CenterChicago, Illinois  60612-3824
Dana-Farber Cancer InstituteBoston, Massachusetts  02115
North Shore University HospitalManhasset, New York  11030
University of Arkansas for Medical SciencesLittle Rock, Arkansas  72205
University of Kansas Medical CenterKansas City, Kansas  66160-7353
Boston Medical CenterBoston, Massachusetts  02118
Brooke Army Medical CenterFort Sam Houston, Texas  78234-6200
Hartford HospitalHartford, Connecticut  06102-5037
Illinois Masonic Medical CenterChicago, Illinois  60657
Eastern Maine Medical CenterBangor, Maine  04401
Franklin Square Hospital CenterBaltimore, Maryland  21237
Baystate Medical CenterSpringfield, Massachusetts  01199
William Beaumont HospitalRoyal Oak, Michigan  48073
Cancer Institute of New JerseyNew Brunswick, New Jersey  08901
University of Nebraska Medical CenterOmaha, Nebraska  68198-3330
Kaiser Permanente Medical Center - Santa ClaraSanta Clara, California  95051-5386
Via Christi Regional Medical CenterWichita, Kansas  67214
Ochsner Clinic FoundationNew Orleans, Louisiana  70121
Carolinas Medical CenterCharlotte, North Carolina  28232-2861
University of Oklahoma Health Sciences CenterOklahoma City, Oklahoma  73104
Scott and White Memorial HospitalTemple, Texas  76508
Saint Anthony Medical CenterRockford, Illinois  61108
Iowa Methodist Medical CenterDes Moines, Iowa  50309
Iowa Lutheran HospitalDes Moines, Iowa  50316-2301
Medical Center of Central GeorgiaMacon, Georgia  31201
Group Health CooperativeSeattle, Washington  98112
Bellin Memorial HospitalGreen Bay, Wisconsin  54301
University of Wisconsin Hospital and ClinicsMadison, Wisconsin  53792-0001
Thompson Cancer Survival CenterKnoxville, Tennessee  37916
Overlook HospitalSummit, New Jersey  07902-0220
Cancer Institute of New Jersey at HamiltonHamilton, New Jersey  08690
MetroHealth Medical CenterCleveland, Ohio  44109
Trinity Cancer Care CenterMinot, North Dakota  58701
Eisenhower Medical CenterRancho Mirage, California  92270
Long Island Jewish Medical CenterNew Hyde Park, New York  11040
Advocate Christ Medical CenterOak Lawn, Illinois  60453
Fred Hutchinson Cancer Research Center/University of Washington Cancer ConsortiumSeattle, Washington  98109
Montefiore Medical CenterBronx, New York  10467-2490
Mount Nittany Medical CenterState College, Pennsylvania  16803
North Colorado Medical CenterGreeley, Colorado  80631
McKee Medical CenterLoveland, Colorado  80539
Cancer Center of Kansas - ChanuteChanute, Kansas  66720
Cancer Center of Kansas - Dodge CityDodge City, Kansas  67801
Cancer Center of Kansas - NewtonNewton, Kansas  67114
Cancer Center of Kansas - SalinaSalina, Kansas  67042
Cancer Center of Kansas - WellingtonWellington, Kansas  67152
Associates in Womens HealthWichita, Kansas  67203
Cancer Center of Kansas - WinfieldWinfield, Kansas  67156
Munson Medical CenterTraverse City, Michigan  49684
Adena Regional Medical CenterChillicothe, Ohio  54601
Grady Memorial HospitalDelaware, Ohio  43015
Fairfield Medical CenterLancaster, Ohio  43130
Avera McKennan Hospital and University Health CenterSioux Falls, South Dakota  57105
McKay-Dee Hospital CenterOgden, Utah  84403
University of South Alabama Mitchell Cancer InstituteMobile, Alabama  36604
Methodist Estabrook Cancer CenterOmaha, Nebraska  68114-4199
Baylor University Medical CenterDallas, Texas  75246
Paoli Memorial HospitalPaoli, Pennsylvania  19301-1792
Elkhart General HospitalElkhart, Indiana  46515
Parkland Memorial HospitalDallas, Texas  75235
Front Range Cancer SpecialistsFort Collins, Colorado  80528
University Medical Center of Southern NevadaLas Vegas, Nevada  89102
Poudre Valley HospitalFort Collins, Colorado  80524
Beebe Medical CenterLewes, Delaware  19958
Memorial HospitalCarthage, Illinois  62321
Hematology and Oncology AssociatesChicago, Illinois  60611
Galesburg ClinicGalesburg, Illinois  61401
Mason District HospitalHavana, Illinois  62644
McDonough District HospitalMacomb, Illinois  61455
BroMenn Regional Medical CenterNormal, Illinois  61761
Proctor HospitalPeoria, Illinois  61614
Perry Memorial HospitalPrinceton, Illinois  61356
Salina Regional Health CenterSalina, Kansas  67401
Mecosta County Medical CenterBig Rapids, Michigan  49307
Community Cancer Center of MonroeMonroe, Michigan  48162
Saint Francis Medical CenterCape Girardeau, Missouri  63701
Creighton University Medical CenterOmaha, Nebraska  68131-2197
Iredell Memorial HospitalStatesville, North Carolina  28677
Bismarck Cancer CenterBismarck, North Dakota  58501
Grandview HospitalDayton, Ohio  45405
Lima Memorial HospitalLima, Ohio  45804
Fulton County Health CenterWauseon, Ohio  43567
Providence Milwaukie HospitalMilwaukie, Oregon  97222
Exempla Lutheran Medical CenterWheat Ridge, Colorado  80033
Eureka HospitalEureka, Illinois  61530
Mercy HospitalCoon Rapids, Minnesota  55433
Graham Hospital AssociationCanton, Illinois  61520
Holy Family Medical CenterDes Plaines, Illinois  60016
Hematology Oncology Associates of Illinois-Highland ParkHighland Park, Illinois  60035
Saint Joseph Medical CenterJoliet, Illinois  60435
Trinity Medical CenterMoline, Illinois  61265-1291
Medical Oncology and Hematology AssociatesDes Moines, Iowa  50309
Bixby Medical CenterAdrian, Michigan  49221
Saint Joseph Mercy HospitalAnn Arbor, Michigan  48106
Fairview-Southdale HospitalEdina, Minnesota  55435
Abbott-Northwestern HospitalMinneapolis, Minnesota  55407
Regions HospitalSaint Paul, Minnesota  55101
Saint Francis Regional Medical CenterShakopee, Minnesota  55379
Altru Cancer CenterGrand Forks, North Dakota  58206
Geisinger Medical GroupState College, Pennsylvania  16801
Fox Valley Hematology and OncologyAppleton, Wisconsin  54911
Alaska Regional HospitalAnchorage, Alaska  99508
Northeast Georgia Medical CenterGainesville, Georgia  30501
Swedish American HospitalRockford, Illinois  61104
Miami Valley HospitalDayton, Ohio  45409
Spartanburg Regional Medical CenterSpartanburg, South Carolina  29303
Eastern Connecticut Hematology and Oncology AssociatesNorwich, Connecticut  06360
Saint Joseph HospitalChicago, Illinois  60657
Cancer Center of Kansas - Fort ScottFort Scott, Kansas  66701
Cancer Center of Kansas-IndependenceIndependence, Kansas  67301
Lawrence Memorial HospitalLawrence, Kansas  66044
Mary Rutan HospitalBellefontaine, Ohio  43311
Wayne HospitalGreenville, Ohio  45331
Wenatchee Valley Medical CenterWenatchee, Washington  98801-2028
Marshfield Clinic Cancer Care at Regional Cancer CenterEau Claire, Wisconsin  54701
UW Cancer Center Johnson CreekJohnson Creek, Wisconsin  53038
Saint Joseph's HospitalMarshfield, Wisconsin  54449
Marshfield Clinic - Weston CenterWeston, Wisconsin  54476
Diagnostic and Treatment CenterWeston, Wisconsin  54476
Marshfield Clinic - Wisconsin Rapids CenterWisconsin Rapids, Wisconsin  54494
Longmont United HospitalLongmont, Colorado  80501
Genesys Regional Medical CenterGrand Blanc, Michigan  48439-8066
Sharp Memorial HospitalSan Diego, California  92123
Martin Memorial Cancer CenterStuart, Florida  34995-9010
Greene Memorial HospitalXenia, Ohio  45385
Greater Baltimore Medical CenterBaltimore, Maryland  21204
Rutherford HospitalRutherfordton, North Carolina  28139
AnMed Health Cancer CenterAnderson, South Carolina  29621
Harold Alfond Center for Cancer CareAugusta, Maine  04330
Union Hospital of Cecil CountyElkton MD, Maryland  21921
Cancer Centers of the Carolinas - Grove CommonsGreenville, South Carolina  29605
Cancer Centers of the Carolinas - SenecaSeneca, South Carolina  29672
Cancer Centers of the Carolinas - SpartanburgSpartanburg, South Carolina  29307
Presbyterian HospitalCharlotte, North Carolina  28233-3549
Mayo Clinic in FloridaJacksonville, Florida  32224
Sutter Roseville Medical CenterRoseville, California  95661
Manchester Memorial HospitalManchester, Connecticut  06040-4188
Washington Hospital CenterWashington, District of Columbia  20010
Sherman HospitalElgin, Illinois  60120-2198
Memorial Medical CenterSpringfield, Illinois  62781
Saint Francis Medical CenterGrand Island, Nebraska  68802
Wellmont Holston Valley Hospital and Medical CenterKingsport, Tennessee  37662
Queen's Medical CenterHonolulu, Hawaii  96813
University of PittsburghPittsburgh, Pennsylvania  15261
University of Alabama at BirminghamBirmingham, Alabama  35294-3300
Providence HospitalMobile, Alabama  36608
Vanderbilt UniversityNashville, Tennessee  37232-6305
University of North CarolinaChapel Hill, North Carolina  27599
Duke University Medical CenterDurham, North Carolina  27710
Northwestern UniversityChicago, Illinois  60611
Memorial Medical CenterModesto, California  95355
Kapiolani Medical Center at Pali MomiAiea, Hawaii  96701
Kapiolani Medical Center for Women and ChildrenHonolulu, Hawaii  96826
Hennepin County Medical CenterMinneapolis, Minnesota  
VA Palo Alto Health Care SystemPalo Alto, California  94304-1207
University of FloridaGainesville, Florida  32610-0277
University of RochesterRochester, New York  14642
Glens Falls HospitalGlens Falls, New York  12801
Saint Alphonsus Regional Medical CenterBoise, Idaho  83706
Holy Cross HospitalFort Lauderdale, Florida  33308
Case Western Reserve UniversityCleveland, Ohio  44106
Yale UniversityNew Haven, Connecticut  06520
Emory UniversityAtlanta, Georgia  30322
Wayne State UniversityDetroit, Michigan  48202
Ohio State University Medical CenterColumbus, Ohio  43210
University of Arizona Health Sciences CenterTucson, Arizona  85724
Straub Clinic and HospitalHonolulu, Hawaii  96813
Lakeland Regional Cancer CenterLakeland, Florida  33805
University of Massachusetts Medical SchoolWorcester, Massachusetts  01605
Riverside Methodist HospitalColumbus, Ohio  43214
Licking Memorial HospitalNewark, Ohio  43055-2899
Cancer Center of Kansas - McPhersonMcPherson, Kansas  67460
Providence Portland Medical CenterPortland, Oregon  97213-3635
California Pacific Medical CenterSan Francisco, California  94115
Dartmouth Hitchcock Medical CenterLebanon, New Hampshire  03756
Mid Dakota ClinicBismarck, North Dakota  58501
Columbus CCOPColumbus, Ohio  43206
Indiana University Medical CenterIndianapolis, Indiana  46202
Weiss Memorial HospitalChicago,, Illinois  60640
University Of VermontBurlington,, Vermont  05403
Presbyterian - Saint Lukes Medical Center - Health OneDenver, Colorado  80218
Kaiser PermanenteSacramento, California  
University of Texas Southwestern Medical CenterDallas, Texas  
University of KentuckyLexington, Kentucky  40536-0098
Wichita CCOPWichita, Kansas  67214-3882
Montana Cancer Consortium CCOPBillings, Montana  59101
Alegent Health Immanuel Medical CenterOmaha, Nebraska  68122
Alegent Health Bergan Mercy Medical CenterOmaha, Nebraska  68124
Flower HospitalSylvania, Ohio  43560-2197
Virginia Mason CCOPSeattle, Washington  98101
Huntsman Cancer Institute/University of UtahSalt Lake City, Utah  84112
Metro-Minnesota CCOPSt. Louis Park, Minnesota  
University of New MexicoAlbuquerque, New Mexico  87131
Tufts Medical CenterBoston, Massachusetts  02111
Cancer Centers of the Carolinas - EasleyEasley, South Carolina  29640
Lakeview HospitalStillwater, Minnesota  55082
Oregon Health and Science UniversityPortland, Oregon  97201
Thomas Jefferson University HospitalPhiladelphia, Pennsylvania  19131
Decatur Memorial HospitalDecatur, Illinois  62526
Virginia Commonwealth UniversityRichmond, Virginia  
Kaiser PermanentePortland, Oregon  97227
Frederick Memorial HospitalFrederick, Maryland  21701
Lankenau HospitalWynnewood, Pennsylvania  19096
Florida HospitalOrlando, Florida  32803
Memorial Health University Medical CenterSavannah, Georgia  31404
Hillcrest Hospital Cancer CenterMayfield Heights, Ohio  44124
University of Chicago Comprehensive Cancer CenterChicago, Illinois  60637-1470
Northern Indiana Cancer Research ConsortiumSouth Bend, Indiana  
University of CincinnatiCincinnati, Ohio  45267-0502
Vince Lombardi Cancer Clinic - OshkoshOshkosh, Wisconsin  54904
Penn State Milton S Hershey Medical CenterHershey, Pennsylvania  17033
Florida Hospital Memorial Medical CenterDaytona Beach, Florida  32117
Southeast Cancer CenterCape Girardeau, Missouri  63703
The Community HospitalMunster, Indiana  46321
Littleton Adventist HospitalLittleton, Colorado  80122
Parker Adventist HospitalParker, Colorado  80138
Froedtert and the Medical College of WisconsinMilwaukee, Wisconsin  53226
Wake Forest University Health SciencesWinston-Salem, North Carolina  27157
OSF Saint Francis Medical CenterPeoria, Illinois  61637
Highlands Oncology Group-BentonvilleBentonville, Arkansas  72712
Saint Edward Mercy Medical CenterFt. Smith, Arkansas  72903
Veteran's Administration Medical CenterLittle Rock, Arkansas  72205
Kaiser Permanente, HaywardHayward, California  94545
Community Hospital of Monterey PeninsulaMonterey, California  93940
Kaiser Permanente-OaklandOakland, California  94611
Saint Joseph HospitalOrange, California  92868
Kaiser Permanente-RichmondRichmond, California  94801
Kaiser Permanente-RosevilleRoseville, California  95661
Sutter General HospitalSacramento, California  95816
Kaiser Permanente-South SacramentoSacramento, California  95823
Kaiser Permanente - SacramentoSacramento, California  95825
Kaiser Permanente-San FranciscoSan Francisco, California  94115
Kaiser Permanente-Santa Teresa-San JoseSan Jose, California  95119
Kaiser Permanente-Santa RosaSanta Rosa, California  95403
Kaiser Permanente-StocktonStockton, California  95210
Kaiser Permanente-VallejoVallejo, California  94589
Kaiser Permanente-Walnut CreekWalnut Creek, California  94596
The Medical Center of AuroraAurora, Colorado  80012
Penrose-Saint Francis HealthcareColorado Springs, Colorado  80907
Memorial Hospital Colorado SpringsColorado Springs, Colorado  80909
Saint Anthony Central HospitalDenver, Colorado  80204
Exempla Saint Joseph HospitalDenver, Colorado  80218
Colorado Cancer Research Program CCOPDenver, Colorado  80224-2522
Saint Mary's Hospital and Regional Medical CenterGrand Junction, Colorado  81502
Saint Mary Corwin Medical CenterPueblo, Colorado  81004
Saint Francis Hospital and Medical CenterHartford, Connecticut  06105
Stamford HospitalStamford, Connecticut  06904
Lombardi Comprehensive Cancer Center at Georgetown UniversityWashington, District of Columbia  20057
Edna Williams Cancer Center at the Baptist Cancer InstituteJacksonville, Florida  32207
M D Anderson Cancer Center- OrlandoOrlando, Florida  32806
Martin Memorial Hospital - SouthStuart, Florida  34997
Martin Memorial Medical Center - NorthStuart, Florida  34994
Atlanta Regional CCOPAtlanta, Georgia  30342
John B Amos Cancer CenterColumbus, Georgia  31904
Saint Joseph's-Candler Health SystemSavannah, Georgia  31405
Oncare Hawaii Inc-POB IIHonolulu, Hawaii  96813
Oncare Hawaii Inc-KuakiniHonolulu, Hawaii  96817
University of HawaiiHonolulu, Hawaii  96813
Saint Luke's Mountain States Tumor InstituteBoise, Idaho  83712
Saint Anthony's HealthAlton, Illinois  62002
Rush - Copley Medical CenterAurora, Illinois  60504
Resurrection HealthcareChicago, Illinois  60631
Cancer Institute at Alexian BrothersElk Grove Village, Illinois  60007
Evanston CCOP-NorthShore University HealthSystemEvanston, Illinois  60201
North Shore Hematology OncologyLibertyville, Illinois  60048
Garneau, Stewart C MD (UIA Investigator)Moline, Illinois  61265
Porubcin, Michael MD (UIA Investigator)Moline, Illinois  61265
Good Samaritan Regional Medical CenterMt. Vernon, Illinois  62864
Community Cancer Center FoundationNormal, Illinois  61761
Illinois CancerCare-Ottawa ClinicOttawa, Illinois  61350
Ottawa Regional Hospital and Healthcare CenterOttawa, Illinois  61350
Pekin Cancer Treatment CenterPekin, Illinois  61554
Illinois Oncology Research Association CCOPPeoria, Illinois  61615
Illinois CancerCare-PeoriaPeoria, Illinois  61615
Illinois Valley HospitalPeru, Illinois  61354
Hematology Oncology Associates of Illinois - SkokieSkokie, Illinois  60076
Carle Clinic-Urbana MainUrbana, Illinois  61801
Saint Francis Hospital and Health CentersBeech Grove, Indiana  46107
Saint Anthony Memorial Health CenterMichigan City, Indiana  46360
Reid Hospital and Health Care ServicesRichmond, Indiana  47374
McFarland ClinicAmes, Iowa  50010
Constantinou, Costas L MD (UIA Investigator)Bettendorf, Iowa  52722
Cedar Rapids Oncology AssociationCedar Rapids, Iowa  52403
Iowa Blood and Cancer Care PLCCedar Rapids, Iowa  52402
Medical Oncology and Hematology Associates-West Des MoinesClive, Iowa  50325
Iowa Oncology Research Association CCOPDes Moines, Iowa  50309
Mercy Medical Center - Des MoinesDes Moines, Iowa  50314
Medical Oncology and Hematology Associates-Des MoinesDes Moines, Iowa  50309
Mercy Medical Center-Sioux CitySioux City, Iowa  51104
Saint Luke's Regional Medical CenterSioux City, Iowa  51104
Covenant Medical CenterWaterloo, Iowa  50702
Cancer Center of Kansas - El DoradoEl Dorado, Kansas  67042
Cancer Center of Kansas-KingmanKingman, Kansas  67068
Cancer Center of Kansas - ParsonsParsons, Kansas  67357
Cancer Center of Kansas - PrattPratt, Kansas  67124
Stormont-Vail Regional Health CenterTopeka, Kansas  66604
Cancer Center of Kansas-Wichita Medical Arts TowerWichita, Kansas  67208
Cancer Center of Kansas - Main OfficeWichita, Kansas  67214
Ochsner Clinic Foundation-Baton RougeBaton Rouge, Louisiana  70809
Associates In Oncology Hematology PC-RockvilleRockville, Maryland  20878
North Shore Medical Center Cancer CenterPeabody, Massachusetts  01960
Berkshire Hematology Oncology PCPittsfield, Massachusetts  01201
Hickman Cancer CenterAdrian, Michigan  49221
Michigan Cancer Research Consortium Community Clinical Oncology ProgramAnn Arbor, Michigan  48106
Oakwood HospitalDearborn, Michigan  48123
Green Bay Oncology - EscanabaEscanaba, Michigan  49431
Grand Rapids Clinical Oncology ProgramGrand Rapids, Michigan  49503
Saint Mary's Health CareGrand Rapids, Michigan  49503
Spectrum Health at Butterworth CampusGrand Rapids, Michigan  49503
Green Bay Oncology - Iron MountainIron Mountain, Michigan  49801
Allegiance HealthJackson, Michigan  49201
Sparrow HospitalLansing, Michigan  48912
Saint Mary Mercy HospitalLivonia, Michigan  48154
Mercy Memorial HospitalMonroe, Michigan  48162
Mercy Health Partners-Mercy CampusMuskegon, Michigan  49443
Saint Joseph Mercy Port HuronPort Huron, Michigan  48060
Saint Mary's of MichiganSaginaw, Michigan  48601
Lakeland HospitalSt. Joseph, Michigan  49085
Miller-Dwan HospitalDuluth, Minnesota  55805
Unity HospitalFridley, Minnesota  55432
Saint John's Hospital - HealtheastMaplewood, Minnesota  55109
Minnesota Oncology Hematology PA-MaplewoodMaplewood, Minnesota  55109
North Memorial Medical Health CenterRobbinsdale, Minnesota  55422
Saint Cloud HospitalSaint Cloud, Minnesota  56303
Park Nicollet Clinic - Saint Louis ParkSaint Louis Park, Minnesota  55416
Minnesota Oncology and Hematology PA-WoodburyWoodbury, Minnesota  55125
Freeman Health SystemJoplin, Missouri  64804
Saint Louis-Cape Girardeau CCOPSaint Louis, Missouri  63141
Missouri Baptist Medical CenterSaint Louis, Missouri  63131
Saint John's Mercy Medical CenterSaint Louis, Missouri  63141
Ozark Health Ventures LLC dba Cancer Research for The Ozarks SpringfieldSpringfield, Missouri  65802
Saint John's HospitalSpringfield, Missouri  65804
Cox Medical CenterSpringfield, Missouri  65807
Saint Vincent HealthcareBillings, Montana  59101
Billings ClinicBillings, Montana  59107-7000
Benefis Healthcare- Sletten Cancer InstituteGreat Falls, Montana  59405
Good Samaritan HospitalKearney, Nebraska  68847
Lincoln Medical Education Foundation Cancer Resource CenterLincoln, Nebraska  68510
Missouri Valley Cancer Consortium CCOPOmaha, Nebraska  68106
Nevada Cancer Research Foundation CCOPLas Vegas, Nevada  89106
Cooper Hospital University Medical CenterCamden, New Jersey  08103
Hunterdon Medical CenterFlemington, New Jersey  08822
Saint Barnabas Medical CenterLivingston, New Jersey  07039
Presbyterian Kaseman HospitalAlbuquerque, New Mexico  87110
Orange Regional Medical CenterMiddletown, New York  10940
Saint Luke's Roosevelt Hospital Center - Saint Luke's DivisionNew York, New York  10025
Columbia University Medical CenterNew York, New York  10032
State University of New York Upstate Medical UniversitySyracuse, New York  13210
Mission Hospitals IncAsheville, North Carolina  28801
Kinston Medical Specialists PAKinston, North Carolina  28501
Saint Alexius Medical CenterBismarck, North Dakota  58501
Summa Barberton HospitalBarberton, Ohio  44203
Aultman Health FoundationCanton, Ohio  44710
Doctors HospitalColumbus, Ohio  43228
Grant Medical CenterColumbus, Ohio  43215
Mount Carmel Health Center WestColumbus, Ohio  43222
Good Samaritan Hospital - DaytonDayton, Ohio  45406
Dayton CCOPDayton, Ohio  45429
Samaritan North Health CenterDayton, Ohio  45415
Blanchard Valley HospitalFindlay, Ohio  45840
Atrium Medical Center-Middletown Regional HospitalFranklin, Ohio  45005-1066
Cleveland Clinic Cancer Center IndependenceIndependence, Ohio  44131
Kettering Medical CenterKettering, Ohio  45429
Marietta Memorial HospitalMarietta, Ohio  45750
Saint Charles HospitalOregon, Ohio  43616
North Coast Cancer CareSandusky, Ohio  44870
Toledo Community Hospital Oncology Program CCOPToledo, Ohio  43617
University of ToledoToledo, Ohio  43614
Saint Vincent Mercy Medical CenterToledo, Ohio  43608
Upper Valley Medical CenterTroy, Ohio  45373
Saint Ann's HospitalWesterville, Ohio  43081
Cleveland Clinic Wooster Specialty CenterWooster, Ohio  44691
Genesis HealthCare SystemZanesville, Ohio  43701
Providence Saint Vincent Medical CenterPortland, Oregon  97225
Columbia River Oncology ProgramPortland, Oregon  97225
Saint Luke's HospitalBethlehem, Pennsylvania  18015
Pocono Medical CenterEast Stroudsburg, Pennsylvania  18301
Scranton Hematology OncologyScranton, Pennsylvania  18510
Mercy HospitalScranton, Pennsylvania  18501
Geisinger Wyoming ValleyWilkes-Barre, Pennsylvania  18711
Mainline Health CCOPWynnewood, Pennsylvania  19096
AnMed Health HospitalAnderson, South Carolina  29621
Greenville CCOPGreenville, South Carolina  29615
Greenville Memorial HospitalGreenville, South Carolina  29605
Upstate Carolina CCOPSpartanburg, South Carolina  29303
Sanford Cancer Center-Oncology ClinicSioux Falls, South Dakota  57104
Harrison Bremerton Hematology and OncologyBremerton, Washington  98310
Columbia Basin Hematology and Oncology PLLCKennewick, Washington  99336
Good Samaritan Community HospitalPuyallup, Washington  98372
Swedish Medical Center-First HillSeattle, Washington  98122-4307
Northwest CCOPTacoma, Washington  98405
Edwards Comprehensive Cancer CenterHuntington, West Virginia  25701
West Virginia UniversityMorgantown, West Virginia  26506
Wheeling HospitalWheeling, West Virginia  26003
Langlade Hospital and Cancer CenterAntigo, Wisconsin  54409
Sacred Heart HospitalEau Claire, Wisconsin  54701
Central Wisconsin Cancer ProgramFond Du Lac, Wisconsin  54935
Saint Vincent HospitalGreen Bay, Wisconsin  54301
Green Bay Oncology Limited at Saint Mary's HospitalGreen Bay, Wisconsin  54303
Saint Mary's HospitalGreen Bay, Wisconsin  54303
Green Bay Oncology at Saint Vincent HospitalGreen Bay, Wisconsin  54301-3526
Aurora BayCare Medical CenterGreen Bay, Wisconsin  54311-6519
Dean Hematology and Oncology ClinicMadison, Wisconsin  53717
Vince Lombardi Cancer Clinic-MarinetteMarinette, Wisconsin  54143
Marshfield Clinic-Minocqua CenterMinocqua, Wisconsin  54548
Oconomowoc Memorial Hospital-ProHealth Care IncOconomowoc, Wisconsin  53066-3896
Green Bay Oncology - Oconto FallsOconto Falls, Wisconsin  54154
Marshfield Clinic at James Beck Cancer CenterRhinelander, Wisconsin  54501
Saint Michael's HospitalStevens Point, Wisconsin  54481
Green Bay Oncology - Sturgeon BaySturgeon Bay, Wisconsin  54235
Aspirus Regional Cancer CenterWausau, Wisconsin  54401
Jupiter Medical CenterJupiter, Florida  33458
University of IllinoisChicago, Illinois  60612
Stony Brook University Medical CenterStony Brook, New York  11794
York HospitalYork, Maine  03909
Lahey Clinic Medical CenterBurlington, Massachusetts  01805
Elkhart ClinicElkhart, Indiana  46515
Saint Jude Medical CenterFullerton, California  92835
Moores University of California San Diego Cancer CenterLA Jolla, California  92093
University of Colorado Cancer Center - Anschutz Cancer PavilionAurora, Colorado  80045
Memorial Healthcare System - Joe DiMaggio Children's HospitalHollywood, Florida  33021
Mount Sinai Medical Center CCOPMiami Beach, Florida  33140
Illinois CancerCare-BloomingtonBloomington%, Illinois  61701
Illinois CancerCare-CantonCanton, Illinois  61520
Illinois CancerCare-CarthageCarthage, Illinois  62321
Illinois CancerCare-EurekaEureka, Illinois  61530
Illinois CancerCare-HavanaHavana, Illinois  62644
Illinois CancerCare-Kewanee ClinicKewanee, Illinois  61443
Illinois CancerCare-MacombMacomb, Illinois  61455
Illinois CancerCare-MonmouthMonmouth, Illinois  61462
Illinois CancerCare-Community Cancer CenterNormal, Illinois  61761
Illinois CancerCare-PekinPekin, Illinois  61603
Illinois CancerCare-PeruPeru, Illinois  61354
Illinois CancerCare-PrincetonPrinceton, Illinois  61356
Illinois CancerCare-Spring ValleySpring Valley, Illinois  61362
Michiana Hematology Oncology PC-ElkhartElkhart, Indiana  46514
Michiana Hematology Oncology PC-PlymouthPlymouth, Indiana  46563
Michiana Hematology Oncology PC-South BendSouth Bend, Indiana  46601
Michiana Hematology Oncology-PC WestvilleWestville, Indiana  46391
Cancer Center of Kansas-LiberalLiberal, Kansas  67901
Saint Agnes HospitalBaltimore, Maryland  21229
University of Michigan University HospitalAnn Arbor, Michigan  48109
Central Care Cancer Center-Carrie J Babb Cancer CenterBolivar, Missouri  65613
University of Missouri - Ellis FischelColumbia, Missouri  65203
Veterans AdministrationColumbia, Missouri  65201
Renown Regional Medical CenterReno, Nevada  89502
Hackensack University Medical CCOPHackensack, New Jersey  07601
Carolinas Medical Center - NortheastConcord, North Carolina  28025
Moses Cone Health System-Regional Cancer CenterGreensboro, North Carolina  27403
Roper HospitalCharleston, South Carolina  29401
Cancer Centers of the Carolinas - FarisGreenville, South Carolina  29605
Cancer Centers of the Carolinas-Greer Medical OncologyGreer, South Carolina  29650
Erlanger Medical CenterChattanooga, Tennessee  37403
Sandra L Maxwell Cancer CenterCedar City, Utah  84720
Intermountain Medical CenterMurray, Utah  84157
Utah Valley Regional Medical CenterProvo, Utah  84603
Dixie Medical Center Regional Cancer CenterSaint George, Utah  84770
Utah Cancer Specialists-Salt Lake CitySalt Lake City, Utah  84106
West Virginia University CharlestonCharleston, West Virginia  25304
Holy Family Memorial HospitalManitowoc, Wisconsin  54221
Wheaton Franciscan Healthcare - Saint JosephMilwaukee, Wisconsin  53210
Vince Lombardi Cancer Clinic-SheboyganSheboygan, Wisconsin  53081
Marshfield Clinic Cancer Care at Saint Michael's HospitalStevens Point, Wisconsin  54481
Aurora Medical Center in SummitSummit, Wisconsin  53066
Vince Lombardi Cancer ClinicTwo Rivers, Wisconsin  54241
Riverview HospitalWisconsin Rapids, Wisconsin  54494
Kansas City Cancer Centers-SouthwestOverland Park, Kansas  66210
University of California at Los Angeles (UCLA )Los Angeles, California  90095
Monter Cancer CenterLake Success, New York  11042
Cancer Centers of Southwest Oklahoma ResearchLawton, Oklahoma  
Arizona Cancer Center at University Medical Center NorthTucson, Arizona  85719
Kuakini Medical CenterHonolulu, Hawaii  96817
Saint Luke's Mountain States Tumor Institute - FruitlandFruitland, Idaho  83619
Arizona Cancer Center at UMC Orange GroveTucson, Arizona  85704
Kaiser Permanente-Deer Valley Medical CenterAntioch, California  94531
Palchak David MDPismo Beach, California  93449
Kaiser Permanente Medical Center-VacavilleVacaville, California  95688
Kaiser Permanente-Rock CreekLafayette, Colorado  80026
Kaiser Permanente Moanalua Medical CenterHonolulu, Hawaii  96819
Wilcox Memorial Hospital and Kauai Medical ClinicLihue, Hawaii  96766-1099
Saint Luke's Mountain States Tumor Institute - MeridianMeridian, Idaho  83642
Saint Luke's Mountain States Tumor Institute - NampaNampa, Idaho  83686
Hinsdale Hematology Oncology Associates IncorporatedHinsdale, Illinois  60521
Spector, David MD (UIA Investigator)Moline, Illinois  61265
Kansas City CCOPPrairie Village, Kansas  66208
Kansas City Cancer Center-Shawnee MissionShawnee Mission, Kansas  66204
Owensboro Mercy Medical CenterOwensboro, Kentucky  42303
Spectrum Health Reed City HospitalReed City, Michigan  49677
Saint FrancisPoughkeepsie, New York  12601
Cleveland Clinic Cancer Center BeachwoodBeachwood, Ohio  44122
The Christ HospitalCincinnati, Ohio  45219
The Mark H Zangmeister CenterColumbus, Ohio  43219
Southern Ohio Medical CenterPortsmouth, Ohio  45662
Cancer Care Associates-MercyOklahoma City, Oklahoma  73120
Saint Charles Medical Center-BendBend, Oregon  97701
Mid-Columbia Medical CenterThe Dalles, Oregon  97058
Susquehanna Cancer CenterWilliamsport, Pennsylvania  17701
Saint Francis HospitalGreenville, South Carolina  29601
Hematology Oncology Associates of Fredericksburg IncFredericksburg, Virginia  22401
Highline Medical Center-Main CampusBurien, Washington  98166
Providence Regional Cancer PartnershipEverett, Washington  98201
Gundersen LutheranLa Crosse, Wisconsin  54601
Alegent Health Lakeside HospitalOmaha, Nebraska  68130
New York Oncology Hematology PC -Albany Medical CenterAlbany, New York  12208
New York Oncology Hematology PC - AlbanyAlbany, New York  12206
New York Oncology Hematology PC - AmsterdamAmsterdam, New York  12010
New York Oncology Hematology PC-HudsonHudson, New York  12534
New York Oncology Hematology PC - LathamLatham, New York  12110
New York Oncology Hematology PC - RexfordRexford, New York  12148
New York Oncology Hematology PC - TroyTroy, New York  12180
Stanford University Hospitals and ClinicsStanford, California  94305
Kaiser Permanente-FranklinDenver, Colorado  80205
Siouxland Hematology Oncology AssociatesSioux City, Iowa  51101
Roger Williams HospitalProvidence, Rhode Island  02908
Mid-Illinois Hematology Oncology AssociatesNormal, Illinois  
Methodist West HospitalWest Des Moines, Iowa  50266-7700
Georgia Health Sciences UniversityAugusta, Georgia  30912
Boca Raton Regional HospitalBoca Raton, Florida  33486
Carle Foundation - Carle Cancer CenterUrbana, Illinois  61801
Michiana Hematology Oncology PC-MishawakaMishawaka, Indiana  46545-1470
Marie Yeager Cancer CenterSaint Joseph, Michigan  49085
Hematology Oncology Associates of Central New York PCEast Syracuse, New York  13057
Summa Akron City HospitalAkron, Ohio  44304
Franciscan St. Francis HealthIndianapolis, Indiana  46237
The Toledo Hospital/Toledo Children's HospitalToledo, Ohio  43606
Sanford USD Medical Center - Sioux FallsSioux Falls, South Dakota  57117-5134
North Shore-LIJ Health System CCOPManhasset, New York  11030
Genesys Regional Medical Center-West Flint CampusFlint, Michigan  48532
Essentia Health Duluth Clinic CCOPDuluth, Minnesota  55805
Essentia Health Saint Mary's Medical CenterDuluth, Minnesota  55805
Sanford Bismarck Medical CenterBismarck, North Dakota  58501
Toledo Clinic Cancer Centers-OregonOregon, Ohio  43616
Geisinger Medical Center-Cancer Center HazeltonHazleton, Pennsylvania  18201
Presbyterian Intercommunity HospitalWhittier, California  90602
Community Howard Regional HealthKokomo, Indiana  46904
Indiana University Health La Porte HospitalLa Porte, Indiana  46350
Saint Joseph Regional Medical Center-MishawakaMishawaka, Indiana  46545-1470
Via Christi Hospital-PittsburgPittsburg, Kansas  66762
PeaceHealth Saint Joseph Medical CenterBellingham, Washington  98225
Aurora Cancer Care-Milwaukee WestWauwatosa, Wisconsin  53226
Christiana Care Health System-Christiana HospitalNewark, Delaware  19718
Illinois Cancer Specialists-NilesNiles, Illinois  60714
Bronson Battle CreekBattle Creek, Michigan  49017
Springfield Regional Medical CenterSpringfield, Ohio  45505
Cleveland Clinic Cancer Center/Fairview HospitalCleveland, Ohio  44111
Marin Cancer Care IncGreenbrae, California  94904
Promise Regional Medical Center-HutchinsonHutchinson, Kansas  65702
Saint Louis Cancer and Breast Institute-South CitySaint Louis, Missouri  63109
Toledo Clinic Cancer Centers-MaumeeMaumee, Ohio  43537-1839
Toledo Clinic Cancer Centers-ToledoToledo, Ohio  43623
Guthrie Clinic-Robert Packer HospitalSayre, Pennsylvania  18840
IU Health Ball Memorial HospitalMuncie, Indiana  47303
Sutter Pacific Medical FoundationSanta Rosa, California  95403
Maine Center for Cancer Medicine and Blood Disorders-ScarboroughScarborough, Maine  04074
Saint Luke's Mountain States Tumor Institute-Twin FallsTwin Falls, Idaho  83301
Ochsner Baptist Medical CenterNew Orleans, Louisiana  70115
Cancer Care Associates-NormanNorman, Oklahoma  73071
Mercy Physicians of Oklahoma-LakesideOklahoma City, Oklahoma  73120
Mercy Cancer Center-West LakesClive, Iowa  50325
Mercy Medical Center-West LakesWest Des Moines, Iowa  50266
Oncare Hawaii Inc - Kapiolani Medical Center at Pali MomiAiea, Hawaii  96701
D N Greenwald CenterMukwonago, Wisconsin  53149
Swedish Medical Center-EdmondsEdmonds, Washington  98026
The Angeles Clinic and Research Institute - West Los Angeles OfficeLos Angeles, California  90025