PEG-asparaginase Treatment in the NOPHO ALL-2008 Protocol: Antibody Formation, Pharmacokinetics, Pharmacodynamics and Side Effects.
Observational Model: Cohort, Time Perspective: Prospective
Bloodsamples and cerebrospinalfluidsamples are collected at certain timepoints during 30 weeks of treatment with PEG-asparaginase. They are analysed for asparagine, asparaginase-enzymeactivity and asparaginase-antibodies.These measures tell about the effect of the drug, PEG-asparaginase.
Up to 30 weeks of treatment
Louise T Henriksen, MD
Aarhus University Hospital
Denmark: The Danish National Committee on Biomedical Research Ethics