Screening for Coronary Artery Disease After Mediastinal Irradiation in Hodgkin Lymphoma Survivors
Objectives:
1. to determine whether MSCT as a screening method of HL survivors treated with
mediastinal irradiation accurately identifies asymptomatic significant coronary artery
disease.
2. to establish the prevelance of coronary abnormalities in HL survivors treated with
mediastinal irradiation
3. to determine the frequency and type of intervention
4. to evaluate the acceptance of screening and asses quality of life among Hl survivors.
Study polulation:
50 long term survivors of HL, previously treatef with mediastinal irradiation without
present evidence of cardiovascular disease
Intervention:
CT-coronary angiography and calcium score, to be performed as a screening method (to
indicate further diagnostic treatent procedures)
Interventional
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Screening
accurately identifying asymptomatic coronary artery disease
to determine whether Ct coronary angiography as a screening method acuurately identifies asymptomatic coronary artery disease in a high risk poulation (HL survivors after mediastinal irradiation)
one year
No
A.D.G. KRol, MD, PhD
Principal Investigator
Leiden University Medical Centre
Netherlands: Medical Ethics Review Committee (METC)
NL31278.058.10
NCT01271127
January 2011
June 2013
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