Type of Study:

Observational

Study Design:

Observational Model: Cohort, Time Perspective: Prospective

Outcome Measure:

To determine whether BCL-B is a survival factor in malignant plasmocytes, we will analyse the level of expression of Bcl-B at the both mRNA and protein levels in a cohort of MGUS and MM patients.

Outcome Description:

To determine whether BCL-B is a survival factor in malignant plasmocytes,we will analyse the level of expression of Bcl-B at the both mRNA and protein levels in a cohort of MGUS and MM patients. The implication of Bcl-B in malignant plasmocyte survival will be evaluated by loss of fucntion experiments (Si-RNA). This will also allow to determine whether Bcl-B is involved in the MGUS to MM transition.

Outcome Time Frame:

6 months

Safety Issue:

No

Principal Investigator

Jean-Gabriel FUZIBET, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

CHU de Nice Service de Médecine Interne et Cancérologie Hôpital de l'Archet

Authority:

France: French Data Protection Authority

Study ID:

09-PP-10

NCT ID:

NCT01270009

Start Date:

November 2010

Completion Date:

November 2013

Related Keywords:

• Multiple Myeloma
• Multiple Myeloma
• Neoplasms, Plasma Cell

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