Inclusion Criteria:

- Patients should sign a written informed consent

- Age between 18-80

- Patients have sigmoid colon cancer that was proved by pathology

- Adequate bone marrow function Hb ≥ 10g/dl (after treatment for simple iron deficiency
anemia) WBC ≥ 3,000/mm3 PLT ≥ 100,000/mm3

- Adequate kidney function Creatinine ≤ 1.5 mg/dl

- No remarkable evidence of heart dysfunction and lung dysfunction

Exclusion Criteria:

- Distant metastasis

- Tumor diameter > 5 cm

- Other organ invasion

- Intestinal obstruction and stent insertion status

- Patient was used steroid

- Patients undergo emergency surgery with multiple symptoms

- Other organ cancer history (except who had radical excision for skin cancer)

- Presence of other serious disease

- Mentally ill patients

- Legally unable to participate in clinical trial

- Lactating or pregnant women

- Patients who will obviously fail to regular follow-up visit or will be off study
voluntarily

- Not eligible to participate for other reasons by doctor's decision