Inclusion Criteria:

- locally advanced or metastatic pancreatic cancer precluding curative surgical
resection and recurrent pancreatic cancer

- Measurable disease by CT scan

- ECOG performance status 0-2

- Life expectancy > 3 months

- laboratory values as follows: 2,000/mm3 < WBC < 15,000/mm3, Platelet count
>75,000/mm3, Total Bilirubin <1.5 mg/dl, Asparate transaminase <150IU/L, Alanine
transaminase < 150 IU/L, Creatinine < 3.0mg/dl

- HLA-A*0201

- Able and willing to give valid written infromed consent

Exclusion Criteria:

- Pregnancy (women of childbearing potential: Refusal or inability to use effective
means of contraception)

- Breast-feeder

- Active or uncontrolled infection

- Prior chemotherapy, radiation therapy, or immunotherapy within 4 weeks

- Serious or uncured wound

- Active or uncontrolled other malignancy

- Steroids or immunosuppressing agent dependent status

- Interstitial pneumonia

- Ileus

- Decision of unsuitableness by principal investigator or physician-in-charge