Inclusion Criteria:

- Unresectable or treatment-resistant patients with Hepatocellular carcinoma

- Measurable disease by CT scan

- ECOG performance status 0-2

- Life expectancy > 3 months

- Laboratory values as follows: 2,000/mm3 < WBC <15,000/mm3, Platelet counts >
75,000/mm3, Total Bilirubin < 1.5 mg/dl, Asparate transaminase < 150IU/L, Alanine
transaminase < 150 IU/L, Creatinine < 3.0mg/dl

- HLA-A*2402

- Able and willing to give valid written informed consent

Exclusion Criteria:

- Pregnancy (women of childbearing potential: Refusal or inability to use effective
means of contraception)

- Brest-feeder

- Active or uncontrolled infection

- Steroids or immunosuppressing agent dependent status

- Active or uncontrolled other malignancy

- Serious or uncured wound

- Decision of unsuitableness by principal investigator or physician-in charge