Cognition in Breast Cancer Patients: The Impact of Cancer-related Stress
Primary hypothesis:
*The adverse effects of cancer and cancer therapy on cognitive function in breast cancer
patients are entirely or partly mediated by stress and the ensuing dysfunction of the
HPA-axis.
Secondary objectives:
- Determining the effect of cancer diagnosis, chemotherapy, disease-related stress, acute
stress response, posttraumatic stress disorder, posttraumatic stress symptoms, anxiety,
and depression on the HPA-axis in breast cancer patients
- Determining the effect of cognitive dysfunction assessed with neuropsychological tests,
cancer diagnosis, chemotherapy, disease-related stress, acute stress response,
posttraumatic stress disorder, posttraumatic stress symptoms, anxiety, and depression
on subjective cognitive function in breast cancer patients
- Prevalence of acute stress response, posttraumatic stress disorder and posttraumatic
stress symptoms, and extent of cancer-specific stress in breast cancer patients treated
with or without chemotherapy
Observational
Observational Model: Case Control, Time Perspective: Prospective
Course of cognitive function
Performance on a battery of cognitive tests
12 months
No
Kerstin Hermelink, PhD
Principal Investigator
Ludwig Maximilian University, Department of Gynecology and Obstetrics
Germany: Ethics Commission
DKH 109132
NCT01264562
January 2011
October 2014
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