Inclusion Criteria:

- Age greater than 18 years

- Diagnostic histopathology of colon cancer stage III (Dukes' stage C)

- Performance Scale Karnofsky greater or equal to 70%

- Have been subjected to resection of the primary neoplastic lesion in more than 8
weeks before start of chemotherapy

- Patient in the first cycle of chemotherapy in adjuvant XELOX regimen.

Exclusion Criteria:

- Patients with a history of autoimmune or inflammatory disease, active infectious
disease, liver disease, renal failure or diabetes mellitus

- Patients with metastatic disease

- Have previously received radiotherapy or chemotherapy

- Use of GCSF-Granulokine ® (growth-stimulating factor granulocyte)

- Use of immunosuppressive drugs, diuretics and supplements of zinc or copper.