Inclusion Criteria:

- Age > 18 years

- Histologically confirmed diagnosis of inoperable progressive or relapsing PVNS/TGCT
OR resectable tumour requesting mutilating surgery

- Demonstrated progressive disease in the last 12 months

- At least one measurable site of disease on MRI/CT scan according to RECIST criteria
(RECIST version 1.1) based on investigator's assessment

- WHO Performance status of 0, 1 or 2

- Adequate organ, electrolyte and marrow function, defined as the following: serum
bilirubin > or =1.5 x ULN, ALT and AST < or = 2.5 x ULN, serum creatinine < or = 1.5
x ULN or creatinine clearance > or = 50 mL/min, absolute neutrophil count (ANC) > or
= 1.5x109/L, platelets > or = 100x109/L, serum lipase < or =1.5 x ULN, magnesium ≥
lower limit of normal (LLN) and potassium ≥ LLN

- Prior adequate physical examination including weight, height, ECOG PS and vital signs
(systolic and diastolic blood pressure, heart rate after at least 5 minutes in supine
position)

- Signed written informed consent form

- Covered by a medical insurance (in countries where applicable)

Exclusion Criteria:

- Pregnant or lactating female or female of child-bearing potential not employing
adequate contraception during the study and for up to three months following
termination of the study

- Known hypersensitivity to nilotinib or to any of the excipients, galactose
intolerance, lactase deficiency or glucose-galactose malabsorption prior to
enrollment

- Acute or chronic uncontrolled liver disease, or severe renal disease

- Impaired cardiac function, including:

- LVEF<50% or below the institutional lower limit of the normal range (whichever is
higher) as determined by echocardiogram or MUGA scan

- History or signs of prior myocardial infarction

- History of unstable angina

- Congenital long QT prolongation

- Personal history of unexplained syncope

- QTc interval ≥ 450 msec on screening ECG

- Other clinically significant heart disease (e.g. bradycardia, congestive heart
failure or uncontrolled hypertension)

- Patient with family history of long QT syndrome, of unexplained syncope or of
unexplained sudden death

- Patients with severe and/or uncontrolled concurrent medical disease that in the
opinion of the investigator could cause unacceptable safety risks or compromise
compliance with the protocol e.g. uncontrolled diabetes, active or uncontrolled
infection, history of pancreatitis

- History of non-compliance to medical regimens

- Concomitant treatment with medicinal products that induce CYP3A4 (e.g. dexamethasone,
phenytoin, carbamazepine, rifampicin, phenobarbital or St. John's Wort), or that
inhibit the CYP3A4 activity (e.g. ketoconazole, itraconazole, voriconazole,
erythromycin, clarithromycin, telithromycin)

- Concomitant treatment with warfarin

- Concomitant treatment with anti-arrhythmic drug (e. g. amiodarone, sotalol,
disopyramide, quinidine, procainamide) or medication that prolongs the QT interval
(e.g. chloroquine, chlorpromazine, domperidone, droperidol, halofantrine,
haloperidol, methadone, pentamidine, pimozide, thioridazine)

- Prior treatment with imatinib except if no progression was demonstrated