Trial Information

Retrospective Study of Ovarian Cancer Patients With Brain Metastasis

The ovarian cancer patient treated at the Department of Obstetrics and Gynecology of the
National Taiwan University Hospital were retrospectively collected. The cancer registration
database was searched for the patients with ovarian carcinoma who brain metastases were also
diagnosed. The medical records of these patients were reviewed with particular attention to
the results of histo-pathological and radiologic reports. Patients with other synchronous
primary brain tumor were excluded. The initial management of primary tumor, including the
surgery and adjuvant chemotherapy, and the clinical courses and disease status, such as
remission, recurrence and progression, were all carefully reviewed. The intra-cranial
lesions were all diagnosed by imaging studies, including brain computed tomography (CT) and
magnetic resonance imaging (MRI) scans. Therapeutic strategies for the metastatic lesions in
the brain were also reviewed. All statistical analyses were performed using the SPSS 13.0
statistical software for Windows. P<0.05 was defined as statistical significance. Survival
was measured from the time of initial diagnosis of brain metastasis until the date of death
or last contact, and was presented by Kaplan-Meier curves.