Inclusion Criteria:

- Patients with a confirmed diagnosis of multiple myeloma (MM)

- Symptomatic MM (multiple myeloma with related organ or tissue damage)

- The MM patients with induction chemotherapy with bortezomib-containing regimens
(bortezomib±steroid±adrimycin)

- The MM patients who performed the peripheral blood stem cell collection and
appropriate stem cell counts (CD34+ cells 2 x 106/kg).

- Age 20-65 years

- Performance status: ECOG (Eastern Cooperative Oncology Group) 0-2.

- Patient has measurable disease, defined as follows: measurable disease is defined as
serum M-protein ≥ 1 g/dL or urine M-protein ≥ 200 mg/24 hours when the patients
started the primary induction therapy.

- Cardiac ejection fraction ≥ 50 % as measured by MUGA or 2D ECHO without clinically
significant abnormalities

- Adequate liver functions: - Transaminase (AST/ALT) < 3 X upper normal value -
Bilirubin < 2 X upper normal value

- Adequate hematological function: Platelet count ≥ 75 x 109/L, hemoglobin ≥ 8 g/dL,
(Prior RBC transfusion or recombinant human erythropoietin use is allowed), absolute
neutrophil count (ANC) ≥ 1.0 x 109/L

- A negative serum or urine pregnancy test prior to treatment must be available both
for pre menopausal women and for women who are < 1 years after the onset of
menopause.

- Expected survival 6 months

- Informed consent

Exclusion Criteria:

- Systemic AL amyloidosis, smoldering multiple myeloma or MGUS.

- Patient with plasma cell leukemia (> 20% plasma cells in the PB and an absolute
plasma cell count of at least 2000/μL)

- Patients who received an extensive radiation therapy within 4 weeks

- Patient is known to be Human Immunodeficiency Virus (HIV) positive.

- Patient has known clinically active Hepatitis B or C.

- Previous renal transplantation

- Severe peripheral neuropathy (Grade 2 or higher as defined by National Cancer
Institute Common Terminology Criteria for Adverse Events (NCI CTCAE) Version 3.0)

- Any other malignancies within the past 5 years except curatively treated non-melanoma
skin cancer or in situ carcinoma of cervix uteri

- Pregnant or lactating women, women of childbearing potential not employing adequate
contraception

- Other serious illness or medical conditions i. Uncontrolled or severe cardiovascular
disease, including myocardial infarction, within 6 months of enrollment, New York
Heart Association (NYHA) Class III or IV heart failure, uncontrolled angina,
clinically significant pericardial disease, or cardiac amyloidosis ii. History of
significant neurological or psychiatric disorders including dementia or seizures iii.
Active uncontrolled infection (viral, bacterial or fungal infection) iv. Active
ulcers detected at gastroscopy v. Other serious medical illnesses

- Known hypersensitivity to any of the study drugs or its ingredients (i.e.,
hypersensitivity to compounds containing boron or mannitol)

- Concomitant administration of any other experimental drug under investigation, or
concomitant chemotherapy, hormonal therapy, or immunotherapy.